Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws
Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws
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DOI：
10.1016/j.joms.2008.09.037
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发表时间：
2009-03-01
影响因子：
1.9
通讯作者：
Wolff, Klaus-Dietrich
中科院分区：
文献类型：
--
作者：
Pautke, Christoph;Bauer, Florian;Wolff, Klaus-Dietrich
目的：迄今为止，双膦酸盐相关颌骨骨坏死（BONJ）的治疗一直受到缺乏成像方式，使坏死的程度可视化。本研究的目的是证明四环素荧光引导下骨切除术在手术治疗BONJ.Patients和方法的可行性：术后10天的术前给予强力霉素的患者患有BONJ.Patients和方法，足够的强力霉素被纳入活骨可视化与认证的医疗灯发射激发光在400至460 nm。强力霉素骨荧光检查可在术中常规、重复性地鉴别活骨和坏死骨。结论：在BONJ的治疗中，保守治疗是可取的。坏死骨可以选择性切除，这意味着BONJ保守手术治疗的改进。(C)2009年美国口腔颌面外科医师协会
Purpose: To date, the therapy of bisphosphonate-associated osteonecrosis of die jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ.Patients and Methods: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm.Results: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence.Conclusion: in the therapy of BONJ, conservative concepts arc to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ. (C) 2009 American Association of Oral and Maxillofacial Surgeons