Leptin in Thrombosis and Atherosclerosis
Leptin in Thrombosis and Atherosclerosis
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DOI：
10.2174/13816128113199990015
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发表时间：
2014-02-01
影响因子：
3.1
通讯作者：
Eitzman, Daniel T.
中科院分区：
文献类型：
--
作者：
Wang, Hui;Luo, Wei;Eitzman, Daniel T.
全球范围的肥胖症流行有可能对慢性和急性血管疾病的流行产生重大影响。除了减肥干预措施，到目前为止已经取得了一定的成功，了解肥胖促进血管疾病过程的机制将是重要的。瘦素是一种由脂肪细胞产生的激素，对它的研究支持了这样一个概念，即脂肪细胞特有的产物可能介导了与肥胖相关的一些血管风险。这篇小型综述提供了一些临床前研究的概述，这些研究证明了瘦素和血管终点之间的因果关系。旨在阻断导致血管疾病的细胞中瘦素介导的信号事件的治疗策略可能被证明对有血管并发症风险的肥胖患者是有益的。
A world-wide obesity epidemic is threatening to have a major impact on the prevalence of chronic and acute vascular diseases. In addition to weight loss interventions, which have met with modest success to date, it will be important to understand mechanisms by which obesity promotes vascular disease processes. Studies of leptin, a hormone produced by the adipocyte, have supported the concept that adipocyte-specific products may be mediating some of the vascular risk associated with obesity. This mini-review provides an overview of some of the preclinical studies demonstrating causal relationships between leptin and vascular endpoints. Therapeutic strategies designed to block leptin-mediated signaling events in cells contributing to vascular disease may prove beneficial in obese subjects at risk for vascular complications.