Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis
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DOI：
10.1016/j.fertnstert.2009.04.038
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发表时间：
2010-08-01
影响因子：
6.7
通讯作者：
Messina, Mark J.
中科院分区：
文献类型：
--
作者：
Hamilton-Reeves, Jill M.;Vazquez, Gabriela;Messina, Mark J.
目的：通过评估大豆蛋白或异黄酮摄入量对男性 T、性激素结合球蛋白 (SHBG)、游离 T 和游离雄激素指数 (FAI) 的影响，确定异黄酮是否通过降低生物可利用 T 来对男性发挥雌激素样作用。设计：检索 PubMed 和 CAB Abstracts 数据库至 2008 年 7 月 1 日，使用数据库特有的受控词汇，例如 soy、异黄酮、金雀异黄酮、植物雌激素、红三叶草、雄激素、睾酮和性激素结合球蛋白。如果[1]成年男性食用大豆食品、大豆分离蛋白或异黄酮提取物（来自大豆或红三叶草）并且[2]评估了循环T、SHBG、游离T或计算的FAI，则选择以英文发表的同行评审研究。数据由两名独立评审员提取。异黄酮暴露直接从研究中提取。主要结果指标：分析了十五个安慰剂对照治疗组的基线和结束指标。此外，涉及 36 个治疗组的 32 份报告在更简单的模型中进行了评估，以确定结果。结果：无论统计模型如何，大豆蛋白或异黄酮摄入量对 T、SHBG、游离 T 或 FAI 均未检测到显着影响。结论：这项荟萃分析的结果表明，大豆食品和异黄酮补充剂均不会改变男性生物可利用 T 浓度的测量值。 （Fertil Steril (R) 2010；94: 997-1007。(C) 2010 美国生殖医学会。）
Objective: To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone-binding globulin (SHBG), free T, and free androgen index (FAI) in men.Design: PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.Main Outcome Measure(s): Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.Result(s): No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.Conclusion(s): The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men. (Fertil Steril (R) 2010; 94: 997-1007. (C) 2010 by American Society for Reproductive Medicine.)