Brains Versus Brawn: An Empirical Test of Barker's Brain Sparing Model
Brains Versus Brawn: An Empirical Test of Barker's Brain Sparing Model
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DOI：
10.1002/ajhb.20979
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Pearson, Osbjorn
中科院分区：
文献类型：
--
作者：
Baker, Jack;Workman, Megan;Pearson, Osbjorn
巴克模型认为，出生时身材矮小的人肌肉质量的减少源于子宫内，这一模型以肌肉为代价，引起了脑组织发育的适应性“保留”。虽然令人信服，但迄今为止，这一模式尚未得到直接测试。本文开发了一个异速生长的框架来检验巴克模型的主要预测，即在那些出生的小肌肉质量是牺牲备用大脑生长，然后评估这一假设使用的数据从第三次全国健康和营养调查（NHANES III）。结果表明，明确支持两种组织的异速生长发育之间的负相关关系，然而，进一步考虑保守的哺乳动物胎儿循环模式表明，系统限制模式的发展损害和“赌注对冲”的反应，在受影响的组织可能提供一个更充分的解释的结果。这一观点非但没有标志着适应性发育编程研究的结束，反而可能为人类生物学领域以及健康和疾病的发育起源开辟一条充满希望的新途径。Am. J.哈姆。22：206-215，2010. (C)2009 Wiley-Liss，Inc.
The Barker model of the in utero origins of diminished muscle mass in those born small invokes the adaptive "sparing" of brain tissue development at the expense of muscle. Though compelling, to date this model has not been directly tested. This article develops an allometric framework for testing the principal prediction of the Barker model-that among those born small muscle mass is sacrificed to spare brain growth-then evaluates this hypothesis using data from the third National Health and Nutrition Examination Survey (NHANES III). The results indicate clear support for a negative relationship between the allometric development of the two tissues; however, a further consideration of conserved mammalian fetal circulatory patterns suggests the possibility that system-constrained patterns of developmental damage and "bet-hedging" responses in affected tissues may provide a more adequate explanation of the results. Far from signaling the end of studies of adaptive developmental programming, this perspective may open a promising new avenue of inquiry within the fields of human biology and the developmental origins of health and disease. Am. J. Hum. Biol. 22:206-215, 2010. (C) 2009 Wiley-Liss, Inc.