Asymmetric epoxidation of α,β-unsaturated ketones under phase-transfer catalyzed conditions
Asymmetric epoxidation of α,β-unsaturated ketones under phase-transfer catalyzed conditions
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DOI：
10.1016/s0040-4039(98)01646-3
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发表时间：
1998-10-08
影响因子：
1.8
通讯作者：
Shioiri, T
中科院分区：
文献类型：
--
作者：
Arai, S;Tsuge, H;Shioiri, T
以手性季铵盐为相转移催化剂，研究了α，β-不饱和酮与H2 O2的不对称环氧化反应。由辛可宁制备的N-[4-（碘）苄基]溴化辛可宁在温和的反应条件下，可有效地用于不对称环氧化反应，生成相应的目标产物，ee值高达92%。(C)1998爱思唯尔科技有限公司。保留所有权利。
Asymmetric epoxidation of a,b-unsaturated ketones with H2O2 was developed using a chiral quaternary ammonium salt as the phase-transfer catalyst. A catalytic amount of N-[4-(iodo)benzyl]cinchoninium bromide, easily prepared from cinchonine, was effective in the asymmetric epoxidation for producing the corresponding desired products with up to 92% ee under mild reaction conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.