DETERMINANTS OF CERVICAL ECTOPIA AND OF CERVICITIS - AGE, ORAL CONTRACEPTION, SPECIFIC CERVICAL INFECTION, SMOKING, AND DOUCHING
DETERMINANTS OF CERVICAL ECTOPIA AND OF CERVICITIS - AGE, ORAL CONTRACEPTION, SPECIFIC CERVICAL INFECTION, SMOKING, AND DOUCHING
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DOI：
10.1016/0002-9378(95)90279-1
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发表时间：
1995-08-01
影响因子：
9.8
通讯作者：
HOLMES, KK
中科院分区：
文献类型：
--
作者：
CRITCHLOW, CW;WOLNERHANSEN, P;HOLMES, KK
目的：我们的目的是评估宫颈异位和宫颈炎的决定因素，特别是在宫颈感染调整后。研究设计：横断面研究采用阴道镜、细胞学和微生物学检查，随机选择764名在性传播疾病诊所就诊的女性和819名连续接受年度常规检查的大学生。结果：在我们控制了潜在的混杂因素后，宫颈异位与口服避孕药和沙眼衣原体感染呈正相关，与两种人群的年龄、性传播疾病患者近期阴道破裂以及大学生吸烟负相关。口服避孕药也与异位半径有关，在口服避孕药使用者中，异位与口服避孕药的持续时间有关。宫颈炎（通过革兰氏染色、巴氏涂片和阴道镜检查评估）与宫颈沙眼衣原体和巨细胞病毒感染（两种人群）以及淋病和宫颈单纯疱疹病毒感染（性传播疾病患者）相关。宫颈炎与异位独立相关，但与口服避孕药无关。然而，在没有宫颈感染的妇女中，口服避孕药与异位区水肿和红斑有关。结论：口服避孕药、年龄、宫颈感染、吸烟和灌洗对宫颈异位有影响，可能影响性传播药物的获得、传播或效果。异位与年轻、口服避孕药和宫颈感染有关；宫颈炎与宫颈异位和沙眼衣原体、淋病奈瑟菌、单纯疱疹病毒和巨细胞病毒感染有关。在没有宫颈感染的妇女中，异位区的水肿和红斑与口服避孕药有关。
OBJECTIVE: Our purpose was to assess determinants of cervical ectopia and cervicitis, specifically after adjustment for cervical infection.STUDY DESIGN: A cross-sectional study was conducted with colposcopic, cytologic, and microbiologic examination of 764 randomly selected women attending a sexually transmitted disease clinic and 819 consecutive college students undergoing routine annual examination.RESULTS: After we controlled for potential confounders, cervical ectopia was positively associated with oral contraception and Chlamydia trachomatis infection and negatively associated with aging in both populations, with recent vaginal doughing in patients with sexually transmitted diseases, and with current smoking in college students. Oral contraception was also associated with the radius of ectopia, and among users of oral contraception ectopia was associated with duration of oral contraception. Cervicitis (evaluated by Gram stain, Papanicolaou smear, and colposcopy) was associated with cervical infection by C. trachomatis and cytomegalovirus (both populations) and with gonorrhea and cervical herpes simplex virus infection (patients with sexually transmitted diseases). Cervicitis was independently associated with ectopia but not with oral contraception after we adjusted for these four cervical infections. However, oral contraception was associated with edema and erythema of the zone of ectopia among women without cervical infection.CONCLUSIONS: Oral contraception, aging, cervical infection, smoking, and douching have effects on cervical ectopia that may influence the acquisition, transmission, or effects of sexually transmitted agents. Ectopia is associated with young age, oral contraception, and cervical infection; cervicitis is associated with ectopia and cervical infection by C. trachomatis, Neisseria gonorrhoeae, herpes simplex virus, and cytomegalovirus. In women without cervical infection, edema and erythema of the zone of ectopia are associated with oral contraception.