HIV-1 risk and vaccine acceptability in the Ugandan military.
HIV-1 risk and vaccine acceptability in the Ugandan military.
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乌干达军队中的 HIV-1 风险和疫苗可接受性。
DOI：
10.1097/00042560-199708150-00008
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Ellner,JJ
中科院分区：
文献类型：
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作者：
Hom,DL;Johnson,JL;Mugyenyi,P;Byaruhanga,R;Kityo,C;Louglin,A;Svilar,GM;Vjecha,M;Mugerwa,RD;Ellner,JJ
1993年7月至10月，对570名19至22岁的志愿者进行了HIV-1筛查，结果血清阳性率为18.3%（95%CI：14.0%，22.6%）。对乌干达人民国防军249名未感染HIV-1的新兵进行了长达18个月的前瞻性随访，以记录HIV-1血清阳性率、血清转换率以及与疫苗可接受性相关的知识和态度。在309人-年的观察中，HIV-1血清发病率为3.56/100人-年（95%CI：1.49，5.62）。在3个月和12个月访视时，就疫苗（特别是抗艾滋病毒疫苗）的接受程度和知识问题对受试者进行了访谈。超过90%的人认为艾滋病毒疫苗不会导致艾滋病毒感染，如果提供，88%的人报告说，如果他们没有感染，他们会接种疫苗。非疫苗预防方法被认为不太可靠;分别只有33.5%和69.3%的队列认为一夫一妻制和使用避孕套有效。在12个月访视时完成疫苗可接受性调查问卷后，向受试者提供批准的多价脑膜炎球菌疫苗，作为一般疫苗接受度的指标。所有受试者均报告接受过至少一次既往疫苗接种，95%的受试者愿意接受脑膜炎球菌疫苗接种。乌干达军队是一个稳定的人群，感染HIV-1的风险很大，可能是疫苗有效性试验的合适人群。
Between July and October 1993, 570 19-to 22-year-old volunteers were screened for HIV-1, with a resulting seroprevalence rate of 18.3%(95% CI: 14.0%, 22.6%). A cohort of 249 HIV-1-noninfected military recruits in the Ugandan Peoples' Defense Forces was followed prospectively for up to 18 months to document rates of HIV-1 seroprevalence, seroconversion, and knowledge and attitudes related to vaccine acceptability. The HIV-1 seroincidence rate was 3.56 per 100 person-years (95% CI: 1.49, 5.62) over 309 person-years of observation. At the 3-and 12-month visits, subjects were interviewed on issues of acceptance and knowledge about vaccines, including anti-HIV vaccines in particular. More than 90% believe that HIV vaccines will not cause HIV infection, and if offered, 88% report that they would take the vaccine if they were not already infected. Nonvaccine prevention methods were considered less reliable; monogamy and condom use were considered effective by only 33.5% and 69.3% of the cohort respectively. After completing the vaccine acceptability questionnaire at the 12-month visit, subjects were offered an approved polyvalent meningococcal vaccine as an indicator of general vaccine acceptance. All subjects reported receiving at least one previous vaccination, and 95% willingly accepted the meningococcal vaccination. The Ugandan military is a stable population at substantial risk for HIV-1 infection and may be a suitable population for vaccine efficacy trials.