The septum transversum mesenchyme induces gall bladder development
The septum transversum mesenchyme induces gall bladder development
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DOI：
10.1242/bio.20135348
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发表时间：
2013-08-15
期刊：
影响因子：
2.4
通讯作者：
Takahashi, Naoki
中科院分区：
文献类型：
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作者：
Saito, Yohei;Kojima, Takuya;Takahashi, Naoki
肝脏、胆囊和腹侧胰腺由腹侧前肠的后部形成。肝诱导后，Sox 17 +/Pdx 1+胰胆共同祖细胞分化为Sox 17 +/Pdx 1-胆囊祖细胞和Sox 17-/Pdx 1+腹侧胰腺祖细胞，但调节这一分化过程的细胞外源性信号尚不清楚。这项研究表明，横隔间充质（STM）在E8.5后向后方生长，与假定的胆囊区域相邻，以诱导胆囊发育。在该诱导过程中，STM衍生的BMP 4通过维持Sox 17表达并抑制Pdx 1表达，诱导与STM相邻的共同祖细胞分化为胆囊祖细胞。此外，STM通过Fgf 10/Fgfr 2b/Sox 9信号通路抑制肝诱导后腹侧前肠后部区域的肝程序的异位激活。因此，STM通过诱导和抑制作用在胆囊发育中起关键作用。(C)2013年。由生物学家有限公司的公司出版这是一个开放获取的文章分发知识共享署名许可证（http：//creativecommons.org/licenses/by/3.0）的条款下，允许无限制地使用，分发和复制在任何媒体上提供的原始工作是正确的归属。
The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1- gall bladder progenitors and Sox17-/Pdx1+ ventral pancreatic progenitors, but the cell-extrinsic signals that regulate this differentiation process are unknown. This study shows that the septum transversum mesenchyme (STM) grows in the posterior direction after E8.5, becoming adjacent to the presumptive gall bladder region, to induce gall bladder development. In this induction process, STM-derived BMP4 induces differentiation from common progenitor cells adjacent to the STM into gall bladder progenitor cells, by maintaining Sox17 expression and suppressing Pdx1 expression. Furthermore, the STM suppresses ectopic activation of the liver program in the posterior region of the ventral foregut following hepatic induction through an Fgf10/Fgfr2b/Sox9 signaling pathway. Thus, the STM plays pivotal roles in gall bladder development by both inductive and suppressive effects. (C) 2013. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.