Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer Immunity.
Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer Immunity.
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人类肿瘤中 ANLN 的综合分析：与癌症免疫相关的预后生物标志物
DOI：
10.1155/2022/5322929
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发表时间：
2022
影响因子：
--
通讯作者：
Lian Y
中科院分区：
文献类型：
--
作者：
Zhang X;Li L;Huang S;Liao W;Li J;Huang Z;Huang Y;Lian Y
Anillin （ANLN）是一种普遍表达的肌动蛋白结合蛋白，在细胞生长、迁移和细胞分裂中起着重要的促肿瘤作用。大量研究表明，ANLN在许多癌症类型中表达上调，并与患者预后和恶性肿瘤特征显著相关。在此，我们对ANLN进行了综合的泛癌症分析，并强调了其潜在的机制，这可能有助于进一步探索潜在的癌症治疗方案。ANLN表达数据提取自在线数据库，包括TCGA、GTEx和CCLE数据库。利用TIMER数据库研究ANLN表达与免疫检查点基因与免疫细胞浸润的关系。采用ScanNeo管道发现新抗原。我们利用KEGG分析和STRING工具来阐明ANLN在癌症发展中的潜在机制。与正常组织相比，ANLN在几乎所有癌组织中都异常过表达。anln高表达水平与多种恶性特征呈正相关，提示其在免疫微环境和不良预后中的潜在作用。此外，在不同类型的癌症中，ANLN的表达与新抗原的数量和不同的磷酸化模式相关，揭示了基因突变积累和高磷酸化在ANLN介导的肿瘤发生中的功能作用。此外，我们发现ANLN是一个重要的调控因子，参与许多信号事件，特别是细胞周期和核胞质运输途径。在各种类型的癌症中，ANLN的表达普遍过表达，它可能对肿瘤的进展和发展有重要影响。ANLN的表达与免疫检查点生物标志物和肿瘤免疫显著相关。总之，这些发现表明，ANLN可能是癌症患者预后的预测指标。
Anillin (ANLN), a ubiquitously expressed actin-binding protein, plays a critical tumor-promoting role in cell growth, migration, and cytokinesis. Numerous studies have suggested that ANLN is upregulated in many cancer types, as well as significantly associated with patient prognosis and malignant cancer characteristics. Herein, we performed an integrated pan-cancer analysis of ANLN and highlighted its underlying mechanism, which may benefit further exploration of the potential therapeutic options for cancer. ANLN expression data were extracted from online databases, including TCGA, GTEx, and CCLE databases. The TIMER database was used to study the association between ANLN expression with immune checkpoint genes and immunocyte infiltration. The ScanNeo pipeline was adopted for neoantigen discovery. KEGG analysis and the STRING tool were used to elucidate the potential mechanism of ANLN in cancer development. ANLN is abnormally overexpressed in almost all cancer tissues compared with normal tissues. The high-ANLN expression level was positively associated with various malignant characteristics, suggesting its potential role in the immune microenvironment and poor prognosis. In addition, ANLN expression was correlated with the number of neoantigens and different phosphorylation pattern in various cancer types, revealing a functional role of genetic mutation accumulation and high phosphorylation in ANLN-mediated oncogenesis. Moreover, we found that ANLN was an important regulatory factor participating in many signaling events, especially the cell cycle and nucleocytoplasmic transport pathways. ANLN expression is generally overexpressed in various types of cancers, and it may have an important influence on tumor progression and development. ANLN expression is significantly associated with the immune checkpoint biomarkers and tumor immunity. Together, these findings suggest that ANLN may be a predictive marker for patient prognosis across cancers.