Treatment of hypertension with oral taurine: experimental and clinical studies
Treatment of hypertension with oral taurine: experimental and clinical studies
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DOI：
10.1007/s00726-002-0212-0
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发表时间：
2002-01-01
期刊：
影响因子：
3.5
通讯作者：
Lombardini, JB
中科院分区：
文献类型：
--
作者：
Militante, JD;Lombardini, JB
口服牛磺酸治疗已被广泛研究作为一种消肿剂。几种高血压大鼠模型已被用于证明饮食中补充牛磺酸可以缓解高血压，以及其他心血管问题。本综述中提到的实验模型包括自发性高血压大鼠、DOCA-盐大鼠、Dahl-S大鼠、肾血管性高血压大鼠、高胰岛素血症大鼠和乙醇处理大鼠。牛磺酸的有益作用也在涉及患有原发性高血压的人类受试者的研究中得到证实。补充牛磺酸6 g/天，持续7天，可使这些患者的血压明显降低。在大鼠和人体研究中，牛磺酸的作用似乎依赖于过度活跃的交感神经系统的调节。然而，牛磺酸对其他类型的心血管问题有积极的影响，因此可能通过一种以上的机制发挥作用。
Oral taurine treatment has been studied extensively as a hypotensive agent. Several rat models of hypertension have been used to prove that dietary taurine supplementation can alleviate high blood pressure, among other cardiovascular problems. Experimental models mentioned in this review are the spontaneously hypertensive rat, the DOCA-salt rat, the Dahl-S rat, the renovascular hypertensive rat, the hyperinsulinemic rat and the ethanol-treated rat. The beneficial effects of taurine were also demonstrated in studies involving human subjects suffering essential hypertension. Taurine supplementation of 6 g/day for as little as 7 days resulted in measurable decreases in blood pressure in these patients. In both rat and human studies, the effects of taurine appeared to be dependent on the modulation of an overactive sympathetic system. However, taurine has positive effects on other types of cardiovascular problems and thus may act through more than one mechanism.