IgG Seroprevalence of COVID-19 among Individuals without a History of the Coronavirus Disease Infection in Daegu, Korea
IgG Seroprevalence of COVID-19 among Individuals without a History of the Coronavirus Disease Infection in Daegu, Korea
复制标题
DOI：
10.3346/jkms.2020.35.e269
复制
发表时间：
2020-07-27
影响因子：
4.5
通讯作者：
Cho, Myung-Rae
中科院分区：
文献类型：
--
作者：
Song, Suk-Kyoon;Lee, Duk-Hee;Cho, Myung-Rae
背景：多个国家对冠状病毒病2019年(新冠肺炎)的血清阳性率研究表明，无论血清阳性率水平如何，未诊断的失踪病例数量都远远多于确诊病例。考虑到韩国从疫情开始就需要进行大规模检测和接触者追踪的战略，韩国未确诊的失踪病例数量可能可以忽略不计。本研究旨在评估韩国新冠肺炎疫情中心大邱区未曾确诊为新冠肺炎患者的人群中新冠肺炎的血清阳性率。方法：对2020年5月25日至6月5日在某高校附属医院门诊就诊的103例患者和95名年龄18~82岁、年龄18~82岁、无新冠肺炎病史的患者和95名监护人进行免疫球蛋白G抗体血清学检测。结果：15例阳性患者中，新冠肺炎阳性率为7.6%(95%可信区间，4.3%~12.2%)。在这些人中，只有一人的密切接触者中出现了聚合酶链式反应确诊病例，13人没有出现新冠肺炎相关症状。患者和监护人之间的血清阳性率相似。根据这一数字，大邱市未确诊的漏报病例数估计是聚合酶链式反应确诊病例数的十几倍。结论：尽管样本数量少且不具代表性，但这是韩国首次对新冠肺炎血清阳性率进行研究。我们的研究表明，即使韩国采取了与其他国家类似的严格战略，未确诊的失踪病例的数量也是相当大的。
Background: Seroprevalence studies of coronavirus disease 2019 (COVID-19) from many countries have shown that the number of undiagnosed missing cases is much larger than that of confirmed cases, irrespective of seroprevalence levels. Considering the strategy of Korea entailing massive testing and contact tracing from the beginning of epidemic, the number of undiagnosed missing cases in Korea may be negligible. This study was conducted to estimate the seroprevalence of COVID-19 among individuals who were never diagnosed with COVID-19 in Daegu, the epicenter of COVID-19 epidemic in Korea.Methods: Serologic testing for immunoglobulin G antibody based on immunochromatographic assay was conducted in 103 patients and 95 guardians aged 18 to 82 years without any history of COVID-19 diagnosis, who visited outpatient clinics of a single university-affiliated hospital from May 25 to June 5, 2020.Results: The estimated seroprevalence was 7.6% (95% confidence interval, 4.3%-12.2%) with 15 positive cases. Among them, only one had a polymerase chain reaction (PCR)-confirmed case among their close contacts and 13 did not experience COVID-19-related symptoms. Seroprevalence was similar between patients and guardians. Based on this figure, the number of undiagnosed missing cases in Daegu was estimated to be a dozen times more than the number of confirmed cases based on PCR testing.Conclusion: Despite the limitation of a small and unrepresentative sample, this is the first study on seroprevalence of COVID-19 in Korea. Our study suggested that the number of undiagnosed missing cases was substantial even with the stringent strategy adopted in Korea, similar to that of other countries.