NEW SYNTHESIS OF DIAZEPAM
NEW SYNTHESIS OF DIAZEPAM
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DOI：
10.1021/jo01297a030
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发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
GATES, M
中科院分区：
文献类型：
--
作者：
GATES, M
An efficient preparation of 7-chloro-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione from 5-chloro-N-methylisatoic anhydride and glycine was devised, and from it, by the action of phenylmagnesium chloride on its N-acetyl derivative followed by treatment with hydroxylamine and cleavage of the resulting desacetyl oxime with sodium bisulfite, diazepam was synthesized. The overall yield is .apprx. 50% from 5-chloroisatoic anhydride.
