Current and future perspectives of functional metabolomics in disease studies-A review
Current and future perspectives of functional metabolomics in disease studies-A review
复制标题
功能代谢组学在疾病研究中的现状和未来展望-综述
DOI：
10.1016/j.aca.2018.04.006
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发表时间：
2018
影响因子：
6.2
通讯作者：
Guowang Xu
中科院分区：
文献类型：
--
作者：
Min Yan;Guowang Xu
功能代谢组学是一个以代谢组学为核心研究代谢物及其相关酶功能的新概念。它克服了传统发现代谢组学主要依靠文献进行生物学解释的缺点。功能代谢组学有许多优点。首先，重点介绍了代谢物及相关代谢酶的功能作用。其次，他们进行体内和体外实验来验证代谢组学的发现，从而提高代谢组学研究的可靠性，产生新的知识。第三，功能代谢组学可以被生物学家用来研究代谢物的功能，以及相关的基因和蛋白质。在这篇综述中，我们总结了功能代谢组学研究中使用的分析、生物学和临床平台。综述了功能代谢组学在癌症、代谢性疾病和生物学表型研究中的最新进展，并对其未来发展进行了展望。由于功能代谢组学的巨大优势，它具有广阔的应用前景。
Functional metabolomics is a new concept, which studies the functions of metabolites and related enzymes focused on metabolomics. It overcomes the shortcomings of traditional discovery metabolomics of mainly relying on literatures for biological interpretation. Functional metabolomics has many advantages. Firstly, the functional roles of metabolites and related metabolic enzymes are focused. Secondly, thein vivoandin vitroexperiments are conducted to validate the metabolomics findings, therefore, increasing the reliability of metabolomics study and producing the new knowledge. Thirdly, functional metabolomics can be used by biologists to investigate functions of metabolites, and related genes and proteins. In this review, we summarize the analytical, biological and clinical platforms used in functional metabolomics studies. Recent progresses of functional metabolomics in cancer, metabolic diseases and biological phenotyping are reviewed, and future development is also predicted. Because of the tremendous advantages of functional metabolomics, it will have a bright future.