Immunotherapy with regulatory T cells in transplantation.
Immunotherapy with regulatory T cells in transplantation.
复制标题
移植中使用调节性 T 细胞进行免疫治疗。
作者：
J. H. Peters;H. Koenen;L. Hilbrands;I. Joosten
基于调节性T细胞（Treg）的免疫疗法在临床移植环境中诱导耐受性具有很大的兴趣。事实上，干细胞移植后Treg输注的首次临床试验最近已经开始。然而，关于人类Treg免疫治疗的许多重要问题仍有待解决。在这篇综述中，我们简要介绍了treg的最新进展，并详细介绍了基于treg的免疫治疗的各种策略。首先，输注体外选择的天然存在的Treg，重点是Treg的分离，扩增，抗原特异性，归巢和稳定性。接下来，讨论了体外诱导Treg输血策略的潜力。最后，针对体内Treg数量或功能增加的治疗进行了讨论。此外，我们还对免疫抑制药物对Tregs的影响进行了综述。在接下来的几年里，我们期待关于Treg免疫疗法在移植中的临床应用的令人兴奋的新数据的发布。
Regulatory T cell (Treg)-based immunotherapy is of great interest to induce tolerance in clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell transplantation have recently begun. However, many important issues regarding human Treg immunotherapy are still to be resolved. In this review, we provide a short update on Tregs and elaborate on various strategies for Treg-based immunotherapy. First, infusion of ex vivo-selected naturally occurring Tregs is addressed, with emphasis on Treg isolation, expansion, antigen specificity, homing and stability. Next, the potential of ex vivo-induced Treg transfusion strategies is discussed. Finally, therapies aimed at in vivo increase of Treg numbers or function are addressed. In addition, we summarize the current knowledge on effects of immunosuppressive drugs on Tregs. In the following years, we expect exciting new data regarding the clinical application of Treg immunotherapy in transplantation to be released.
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影响因子：
20.3
作者：
Taylor, PA;Lees, CJ;Blazar, BR
通讯作者：
Blazar, BR
影响因子：
4.3
作者：
Jones, SC;Murphy, GF;Korngold, R
通讯作者：
Korngold, R
影响因子：
20.3
作者：
Zhao, Dongchang;Zhang, Chunyan;Zeng, Defu
通讯作者：
Zeng, Defu
影响因子：
20.3
作者：
Beriou, Gaelle;Costantino, Cristina M.;Hafler, David A.
通讯作者：
Hafler, David A.
DOI：
10.1097/01.asn.0000057540.98231.c1
发表时间：
2003-06-01
影响因子：
13.6
作者：
Salama, AD;Najafian, N;Sayegh, MH
通讯作者：
Sayegh, MH