Mobile DNA in Health and Disease.

Mobile DNA in Health and Disease.
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DOI:
10.1056/nejmra1510092
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发表时间:
2017-07-27
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Moran JV
Moran JV
中科院分区:
其他
文献类型:
--
作者:
Kazazian HH Jr;Moran JV

文献摘要

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超过一半的人类基因组来自转座因子(也被称为移动的DNA或“跳跃基因”);随着时间的推移,这些因子中的一些已经被重新利用以服务于进化。“活的”移动的元素是遗传疾病的罕见原因。
More than half the human genome is derived from transposable elements (also known as mobile DNA or “jumping genes”); some of these elements have been repurposed over time in the service of evolution. “Live” mobile elements are a rare cause of genetic disease.