Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.
Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.
复制标题
山羊关节炎脑炎慢病毒的跨膜蛋白寡聚体在患有进行性关节炎的山羊中具有免疫优势。
DOI：
10.1128/jvi.66.5.3247-3250.1992
复制
发表时间：
1992
影响因子：
5.4
通讯作者：
Cheevers,WP
中科院分区：
文献类型：
--
作者：
McGuire,TC;KnowlesJr,DP;Davis,WC;Brassfield,AL;Stem,TA;Cheevers,WP
为了剖析羊关节炎-脑炎慢病毒诱导关节炎的机制，一种未定义的免疫优势病毒糖蛋白gp90 (G. C. Johnson， A. F. Barbet， P. klejer - anderson，和T. C. McGuire，感染性。免疫学杂志，41:657-665,1983)。gp90单克隆抗体和env基因产物特异性抗血清证明gp90是跨膜蛋白（TM）二聚体。进行性关节炎山羊对寡聚物和单体（38-kDa） TM抗体滴度高。
To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env gene products demonstrated that gp90 was a transmembrane protein (TM) dimer. Goats with progressive arthritis had high antibody titers to oligomeric and monomeric (38-kDa) TM.