Serum Adiponectin, Leptin, C-Peptide, Homocysteine, and Colorectal Adenoma Recurrence in the Polyp Prevention Trial
Serum Adiponectin, Leptin, C-Peptide, Homocysteine, and Colorectal Adenoma Recurrence in the Polyp Prevention Trial
复制标题
DOI：
10.1158/1055-9965.epi-09-1082
复制
发表时间：
2010-06-01
影响因子：
3.8
通讯作者：
Cross, Amanda J.
中科院分区：
文献类型：
--
作者：
Bobe, Gerd;Murphy, Gwen;Cross, Amanda J.
背景：血清脂联素、瘦素、C肽和同型半胱氨酸是肥胖、高胰岛素血症和慢性炎症的指标，这些都与结直肠癌有关。目的：确定血清脂联素、瘦素、C肽和同型半胱氨酸是否与脂肪、纤维、水果和蔬菜、黄酮醇或干豆摄入和结直肠腺瘤复发有关。方法：采用Logistic回归方法，我们估计了627名来自息肉预防试验对照组的腺瘤复发的优势比(OR)和95%可信区间(95%CI)。这项为期4年的试验检验了低脂、高纤维、高纤维的试验的有效性结果：血清C-肽和同型半胱氨酸水平与纤维、水果和蔬菜摄入量、黄酮醇摄入量呈负相关，与脂肪热量百分比呈正相关(P均<0.05)。
Background: Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer.Aims: To determine whether serum adiponectin, leptin, C-peptide, and homocysteine are associated with fat, fiber, fruit and vegetable, flavonol, or dry bean intake and colorectal adenoma recurrence.Methods: Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (95% CI) for adenoma recurrence in 627 participants from the control arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence.Results: Serum concentrations of C-peptide and homocysteine were inversely related to fiber, fruit and vegetable, and flavonol intake and positively related to percentage of calories from fat (all P-trend =