EXERCISE TRAINING ATTENUATES BAROREFLEX REGULATION OF NERVE ACTIVITY IN RABBITS
EXERCISE TRAINING ATTENUATES BAROREFLEX REGULATION OF NERVE ACTIVITY IN RABBITS
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DOI：
10.1152/ajpheart.1988.255.4.h974
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发表时间：
1988-10-01
影响因子：
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通讯作者：
BISHOP, VS
中科院分区：
文献类型：
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作者：
DICARLO, SE;BISHOP, VS
在清醒家兔上观察了跑台耐力运动训练前和训练后8周动脉压变化时心率（HR）和肾交感神经活动（RSNA）的压力反射控制。运动诱发的心动过缓（静息和相同负荷时HR降低）用于记录心血管训练效果。在29.4 m/min，20%等级下，训练后HR显著低于训练前值（295 . ±. 6次/分钟vs. 361 . ±. 8次/min，P < 0.05）。 在家兔下腔静脉（IVCO）周围植入封堵器，动脉和静脉导管，并在肾交感神经周围植入记录电极。压力感受性反射介导的HR和RSNA的变化，以25毫米汞柱的平均动脉压（MAP）的下降和增加，分别通过膨胀IVCO或渐进式输注苯肾上腺素。训练后，RSNA和HR的压力感受性反射控制范围（最大反应减去最小反应）显著减弱（209 . ±. 12对413 +-。14%和123 .+-. 16对162 +-。8次/分）。此外，训练后HR和RSNA的压力反射控制斜率显著减弱（4.17 . ±. 0.35 vs. 8.32 vs. 8.32 .+-. 0.23%/mmHg和2.57 ±. 0.4 vs. 4.14 .+-。0.4 beats. cntdot. min-1. mmHg-1）。这些数据表明，耐力运动训练显着衰减压力反射控制清醒家兔的心率和RSNA。
Baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) during changes in arterial pressure were examined in conscious rabbits before and after 8 wk of treadmill endurance exercise training. Exercise-induced bradycardia (decreased HR at rest and at identical workloads) was used to document a cardiovascular training effect. At 29.4 m/min, 20% grade, posttraining HR was significantly lower than pretraining values (295 .+-. 6 beats/min vs. 361 .+-. 8 beats/min, P < 0.05). Rabbits were instrumented with an occluder around the inferior vena cava (IVCO), arterial and venous catheters, and recording electrodes around renal sympathetic nerves. Baroreflex-mediated changes in HR and RSNA to a 25-mmHg decrease and increase in mean arterial pressure (MAP) were obtained by inflating the IVCO or progressive infusion of phenylephrine, respectively. After training, the range (maximum response minus minimum response) of baroreflex control of RSNA and HR was significantly attenuated (209 .+-. 12 vs. 413 .+-. 14% and 123 .+-. 16 vs. 162 .+-. 8 beats/min). In addition, the slope of baroreflex control of HR and RSNA was significantly attenuated after training (4.17 .+-. 0.35 vs. 8.32 vs. 8.32 .+-. 0.23%/mmHg and 2.57 .+-. 0.4 vs. 4.14 .+-. 0.4 beats .cntdot. min-1 .cntdot. mmHg-1). These data demonstrate that endurance exercise training significantly attenuated baroreflex control of HR and RSNA in conscious rabbits.