Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain.
Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain.
复制标题
低剂量率放射治疗大鼠脑中可移植性胶质肉瘤。
DOI：
10.1007/bf00167063
复制
发表时间：
1990
影响因子：
3.9
通讯作者：
Kim,SH
中科院分区：
文献类型：
--
作者：
Kim,JH;Alfieri,AA;Rosenblum,M;Bravo,S;Kim,SH
低能量放射性核素间质近距离放射治疗与外照射放射治疗联合治疗原发性脑恶性胶质瘤已成为一种广泛应用的方法。脑肿瘤低剂量率近距离放射治疗的放射生物学研究很少。由于我们最近开发了一种无创低剂量率放射治疗模型，用于治疗在大鼠脑中生长的可移植9 L胶质肉瘤，我们进行了一系列放射生物学研究，以确定对肿瘤和正常脑组织的剂量率效应。以TCD 50（控制50%肿瘤控制的辐射剂量）为终点，我们得到的结果表明，肿瘤控制率高度依赖于剂量率和输送到肿瘤的总剂量。剂量率为100 c戈伊/min、120 c戈伊/hr和40 c戈伊/hr的TCD 50分别为25戈伊、80戈伊和100戈伊。高剂量率照射（100 cGy/min）对正常组织的影响最明显。高剂量率全脑照射的LD_（50）为29戈伊。相比之下，大多数接受低剂量率放射治疗的动物在长达一年的随访中表现相当正常。辐射脑的晚期组织病理学变化通常包括血管和白色物质坏死，尽管这种变化的程度在长期存活者中表现出相当大的个体差异。
Interstitial brachytherapy with low energy radionuclides is becoming widely used in conjunction with external beam radiotherapy in the treatment of primary malignant gliomas of the brain. Few radiobiological studies have been carried out with low dose rate brachytherapy for brain tumors. Since we have recently developed a non-invasive low dose rate radiotherapy model for the treatment of transplantable 9L gliosarcoma growing in the rat brain, we carried out a series of radiobiological studies to determine the dose rate effect on the tumor and normal brain tissue. Using TCD50(the radiation dose to control 50% tumor control) as the endpoints, we obtained the results indicating that the tumor control rate was highly dependent on the dose rate and the total dose delivered to the tumor. The TCD50of dose rates ranging from 100 cGy/min, 120 cGy/hr, and 40 cGy/hr were 25 Gy, 80 Gy, and 100 Gy, respectively. The normal tissue effects were most pronounced with high dose rate irradiation (100 cGy/min). The LD50for high dose rate irradiation to the whole brain was 29 Gy. In contrast, the majority of animals treated with low dose rate radio-therapy behaved quite normal up to a year follow-up. The late histopathological changes of the irradiated brain usually consisted of vascular and white matter necrosis, although the extent of such changes showed a considerable individual variation within the long-term survivors.