Bacterial Signal Transduction Systems for Environmental Adaptation and Their Inhibitors
Bacterial Signal Transduction Systems for Environmental Adaptation and Their Inhibitors
复制标题
环境适应细菌信号转导系统及其抑制剂
DOI：
--
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
R. Utsumi
中科院分区：
文献类型：
--
作者：
R. Utsumi
细菌双组分信号转导系统在环境适应中起着关键作用。在这篇小综述中，阐明了大肠杆菌中的两个TCS：PhoP/PhoQ系统，其感测细胞外Mg 2+并控制基因的表达以适应环境Mg 2+剥夺（Mg 2+调节子）;和EvgA/EvgS，一种激活药物外排泵基因表达的信号转导系统。此外，基于抑制枯草芽孢杆菌中的YycF/YycG信号转导，描述了开发新的一类抗菌剂的新策略。
Bacterial two-component signal transduction systems (TCSs) play a pivotal role in environmental adaptation. In this minireview, two TCSs in Escherichia coli are clarified: the PhoP/PhoQ system, which senses extracellular Mg2+ and controls the expression of the genes for adaptation to environmental Mg2+ deprivation (Mg2+ regulon); and EvgA/EvgS, a signal transduction system that activates expression of the drug efflux pump genes. Furthermore, based on the inhibition of YycF/YycG signal transduction in Bacillus subtilis, a novel strategy for developing a new class of antibacterial agents is described.