ACE1 polymorphism and progression of SARS
ACE1 polymorphism and progression of SARS
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DOI：
10.1016/j.bbrc.2004.08.208
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发表时间：
2004-10-22
影响因子：
3.1
通讯作者：
Sasazuki, T
中科院分区：
文献类型：
--
作者：
Itoyama, S;Keicho, N;Sasazuki, T
我们假设遗传易感性影响SARS的进展。血管紧张素转换酶1（ACE 1）插入/缺失（I/D）多态性与成人呼吸窘迫综合征（ARDS）的发生有关，也被认为是SARS患者肺组织损伤的关键因素。这次，在44名越南SARS病例中进行了多态性基因分型，其中103名健康对照与SARS患者有过接触，50名对照没有任何接触史。SARS病例分为非低氧血症组和低氧血症组。尽管样本量小，D等位基因的频率显着高于低氧血症组比在非低氧血症组（p = 0.013），而SARS病例和对照组之间没有显着差异，无论接触史。ACE 1可能是影响SARS肺炎进展的候选基因之一。(C)2004年爱思唯尔公司All rights reserved.
We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p = 0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS. (C) 2004 Elsevier Inc. All rights reserved.