Interleukin-6 as a Therapeutic Target in Candidate Inflammatory Diseases
Interleukin-6 as a Therapeutic Target in Candidate Inflammatory Diseases
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DOI：
10.1038/clpt.2009.313
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发表时间：
2010-04-01
影响因子：
6.7
通讯作者：
Nishimoto, N.
中科院分区：
文献类型：
--
作者：
Nishimoto, N.
白细胞介素（IL）-6是一种多功能细胞因子，调节免疫反应，炎症和造血。尽管IL-6发挥几种重要的生理作用，但IL-6的失调过度产生导致各种临床症状和实验室测试结果异常。IL-6的过度产生已被证明是许多自身免疫性和炎性疾病的基础，包括类风湿性关节炎（RA）、全身性发作的幼年特发性关节炎（soJIA）和Castleman病，以及恶性肿瘤如多发性骨髓瘤和间皮瘤。IL-6信号传导的阻断可以治疗以病理性IL-6过度产生为特征的疾病。本文综述了IL-6作为候选炎症性疾病的治疗靶点。
Interleukin (IL)-6 is a multifunctional cytokine that regulates immune response, inflammation, and hematopoiesis. Although IL-6 plays several important physiological roles, deregulated overproduction of IL-6 causes various clinical symptoms and abnormalities in laboratory test results. Overproduction of IL-6 has been shown to underlie a number of autoimmune and inflammatory diseases, including rheumatoid arthritis (RA), systemic-onset juvenile idiopathic arthritis (soJIA), and Castleman's disease, as well as malignancies such as multiple myeloma and mesothelioma. Blocking of IL-6 signaling may be therapeutic in diseases characterized by pathological IL-6 overproduction. This review provides an overview of IL-6 as a therapeutic target in candidate inflammatory diseases.