Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions.
Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions.
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8.7 MeV 质子和 23.5 MeV 氦 3 离子在人淋巴细胞中诱导染色体畸变。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Moquet
中科院分区：
文献类型：
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作者：
A. Edwards;D. Lloyd;J. Prosser;P. Finnon;J. Moquet
本文描述了在轨道段模式下用 8.7 MeV 质子和 23.5 MeV 氦 3 离子照射薄血液样本。人类淋巴细胞的染色体畸变已被评分。双着丝粒产量和剂量（Gy）之间的关系为：对于质子，Y = 0.044 D + 0.058 D2；对于氦离子，Y = 0.394 D。将这些结果与其他使用质子的实验室的数据进行比较，并尝试协调差异。一个意想不到的观察结果是，氦离子和质子的线性系数之比约为 9，而 l.e.t. 的比率约为 9。值为 4.5。这与当前的理论不一致，当前的理论预测线性系数应与 l.e.t 成正比。我们讨论了实验中可能的错误来源，但没有充分解释这些差异。
This paper describes the irradiation of thin samples of blood with 8.7 MeV protons and 23.5 MeV helium-3 ions in the track segment mode. Chromosome aberrations in human lymphocytes have been scored. The relationship between dicentric yield and dose in Gy was Y = 0.044 D + 0.058 D2 for protons and Y = 0.394 D for helium ions. These results are compared with data from other laboratories using protons and an attempt is made to reconcile differences. An unexpected observation was that the ratio of the linear coefficients for helium ions and protons was about 9 whereas the ratio of the l.e.t. values was 4.5. This disagrees with current theory which predicts that the linear coefficients should be proportional to l.e.t. Possible sources of error in our experiments are discussed but do not adequately account for the discrepancies.