The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
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DOI：
10.1038/s41586-020-2818-3
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发表时间：
2020-09-30
期刊：
影响因子：
64.8
通讯作者：
Paabo, Svante
中科院分区：
文献类型：
--
作者：
Zeberg, Hugo;Paabo, Svante
最近的一项遗传关联研究 (1) 确定 3 号染色体上的一个基因簇是感染严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 后发生呼吸衰竭的风险位点。另一项由 3,199 名 2019 年冠状病毒病 (COVID-19) 住院患者和对照个体组成的独立研究 (COVID-19 Host Genetics Initiative)(2) 表明，该群体是 SARS-CoV-2 感染和住院后出现严重症状的主要遗传风险因素。在这里，我们表明，这种风险是由从尼安德特人遗传的约 50 kb 大小的基因组片段赋予的，南亚约 50% 的人和欧洲约 16% 的人携带。重症 COVID-19 的风险是由从尼安德特人遗传的基因组片段赋予的，南亚和欧洲约 50% 和 16% 的人分别携带。
A recent genetic association study(1) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)(2) comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.Risk of severe COVID-19 is conferred by a genomic segment that is inherited from Neanderthals and is carried by around 50% and 16% of people in south Asia and Europe, respectively.