Myocardial T1 and extracellular volume fraction mapping at 3 tesla.
Myocardial T1 and extracellular volume fraction mapping at 3 tesla.
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DOI：
10.1186/1532-429x-13-75
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发表时间：
2011-11-28
期刊：
影响因子：
--
通讯作者：
Bluemke DA
中科院分区：
文献类型：
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作者：
Lee JJ;Liu S;Nacif MS;Ugander M;Han J;Kawel N;Sibley CT;Kellman P;Arai AE;Bluemke DA
比较3T时11次心跳（HB）和17次HB改良锁锁反转恢复（MOLLI）脉冲序列，建立心肌T1和细胞外体积分数（ECV）的初步参考值。采用11hb和17hb MOLLI序列，在256 × 180矩阵上，空间分辨率为1.75 × 1.75 × 10 mm， TI初始值为110 ms， TI增量为80 ms，翻转角度为35°，TR/TE = 1.9/1.0 ms，对幻影和正常志愿者进行3T扫描。所有志愿者均给予钆- dtpa (Magnevist, 0.15 mmol/kg)，并在注射造影剂后3.5-23.5分钟在同一造影剂前位置进行多次造影剂后MOLLI扫描。注射后12-30分钟也可获得晚期钆增强（LGE）图像。11 HB和17 HB MOLLI的T1值在假体和志愿者中都显示出良好的一致性。对比前心肌和血液T1平均值分别为1315±39 ms和2020±129 ms。ECV在对比后8.5 ~ 23.5分钟稳定，平均为26.7±1.0%。11hb MOLLI是一种更快的3T高分辨率心肌T1制图方法。ECV分数是稳定的，在较宽的时间范围内对比管理。
To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus. T1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 ± 39 ms and 2020 ± 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 ± 1.0%. The 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.