Extremely high mortality rates among hemodialysis patients with COVID-19 before the era of SARS -CoV-2 vaccination: results from a large database from the North of Poland
Extremely high mortality rates among hemodialysis patients with COVID-19 before the era of SARS -CoV-2 vaccination: results from a large database from the North of Poland
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DOI：
10.20452/pamw.16028
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发表时间：
2021-08-30
影响因子：
4.8
通讯作者：
Tylicki, Leszek
中科院分区：
文献类型：
--
作者：
Puchalska-Reglinska, Ewelina;Debska-Slizien, Alicja;Tylicki, Leszek
引言初步报告表明，在接受肾脏替代治疗的患者中，SARS-CoV-2感染的发病率和死亡率较高。目的我们旨在描述血液透析患者中COVID-19的发病率和结局。患者和方法我们进行了一项回顾性多中心队列研究，比较了从大流行开始到SARS-CoV-2疫苗接种计划开始期间血液透析患者与普通成年人群的COVID-19发病率和死亡率。研究人群包括2019年12月31日在波兰波美拉尼亚省14个透析单位中任何一个接受血液透析的所有患者，以及2020年1月1日至2021年1月31日期间开始长期血液透析的所有个体，共计1567例患者。关于一般人口的数据来自卫生当局的报告。结果血液透析患者SARS-CoV-2感染的绝对累积发病率为22.4%，按年龄标准化后，是普通人群的3.98倍（P
INTRODuCTION Preliminary reports suggested high incidence and mortality rates of SARS-CoV-2 infec-tion in patients receiving kidney replacement therapy. OBjECTIvES We aimed to describe the incidence and outcomes of COVID-19 in hemodialysis patients. PATIENTS AND METNODS We conducted a retrospective multi center cohort study on the incidence and mortality of COVID-19 in hemodialysis patients as compared with the general adult population in the period from the beginning of the pandemic until the commencement of the SARS-CoV-2 vaccination program. The study population included all patients who were receiving hemodialysis in any of the 14 dialysis units of Pomerania Province, Poland on December 31, 2019 and all individuals who were starting long-term hemodialysis between January 1, 2020 and January 31, 2021, amounting to a total of 1567 patients. Data on the general population were obtained from reports of the health authorities. RESuLTS The absolute cumulative incidence of SARS-CoV-2 infection in hemodialysis patients was 22.4%, and after standardization for age it was 3.98-fold higher compared with the general population (P