IDOMAL: an ontology for malaria
IDOMAL: an ontology for malaria
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DOI：
10.1186/1475-2875-9-230
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发表时间：
2010-08-10
期刊：
影响因子：
3
通讯作者：
Louis, Christos
中科院分区：
文献类型：
--
作者：
Topalis, Pantelis;Mitraka, Elvira;Louis, Christos
背景资料：本体正迅速成为设计高效信息技术工具的必要条件，特别是数据库，因为它们允许使用人类和机器都理解的逻辑规则和定义的术语来组织存储的数据。因此，数据库和相关资源的使用和互操作性都得到加强。希望IDOMAL，疟疾的本体论将证明是一个有价值的工具时，在疟疾的研究和控制measures.Methods：OBOEdit 2软件被用于本体论的建设。IDOMAL是基于基本形式本体论（BFO），并遵循由OBO铸造consortion.Results：疟疾本体论的第一个版本，涵盖了临床和流行病学方面的疾病，以及疾病和病媒生物学的规则。IDOMAL旨在以后成为更大的媒介传播疾病本体的核心站点，其本身将是传染病（IDO）的大型本体的扩展。后者目前正在开发的框架内的一个大的国际合作effort.Conclusions：IDOMAL，已经免费提供的第一个版本，将形成一套本体的一部分，将被用来驱动IT工具和数据库，专门建造，以帮助控制疟疾，后来，其他病媒传播的疾病。这个套件已经包括这里描述的本体以及一段时间以来可用的杀虫剂抗性本体。正在开发其他组件并将其引入IDOMAL。
Background: Ontologies are rapidly becoming a necessity for the design of efficient information technology tools, especially databases, because they permit the organization of stored data using logical rules and defined terms that are understood by both humans and machines. This has as consequence both an enhanced usage and interoperability of databases and related resources. It is hoped that IDOMAL, the ontology of malaria will prove a valuable instrument when implemented in both malaria research and control measures.Methods: The OBOEdit2 software was used for the construction of the ontology. IDOMAL is based on the Basic Formal Ontology (BFO) and follows the rules set by the OBO Foundry consortium.Results: The first version of the malaria ontology covers both clinical and epidemiological aspects of the disease, as well as disease and vector biology. IDOMAL is meant to later become the nucleation site for a much larger ontology of vector borne diseases, which will itself be an extension of a large ontology of infectious diseases (IDO). The latter is currently being developed in the frame of a large international collaborative effort.Conclusions: IDOMAL, already freely available in its first version, will form part of a suite of ontologies that will be used to drive IT tools and databases specifically constructed to help control malaria and, later, other vector-borne diseases. This suite already consists of the ontology described here as well as the one on insecticide resistance that has been available for some time. Additional components are being developed and introduced into IDOMAL.