Skilled independent control of individual motor units via a non-invasive neuromuscular-machine interface
Skilled independent control of individual motor units via a non-invasive neuromuscular-machine interface
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DOI：
10.1088/1741-2552/ac35ac
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发表时间：
2021-12-01
影响因子：
4
通讯作者：
Carmena, Jose M.
中科院分区：
文献类型：
--
作者：
Formento, Emanuele;Botros, Paul;Carmena, Jose M.
目标。脑机接口(BMI)具有增强人类功能和恢复残疾人独立性的潜力，但非侵入性和性能之间的妥协限制了它们的相关性。接近。在这里，我们假设，一个非侵入性的神经肌肉-机器接口，提供肌肉中单个运动单位的实时神经反馈，可以使独立的运动单位控制达到适合高性能BMI应用的程度。主要结果。经过6天的训练，8名参与者逐渐学会了熟练和独立地控制三个二头肌运动单位，以完成2D中锋任务。我们表明，神经反馈使运动单位的活动在很大程度上违反了在坡道和保持等长收缩期间观察到的招募限制，被认为限制了单个运动单位的可控性。最后，参与者通过拼写任务演示了单独的运动单元是否适合为一般应用程序提供动力。意义重大。这些结果说明了感应电机系统的灵活性，并突出了单个电机单元作为BMI应用程序的一种有前途的控制来源。
Objective. Brain-machine interfaces (BMIs) have the potential to augment human functions and restore independence in people with disabilities, yet a compromise between non-invasiveness and performance limits their relevance. Approach. Here, we hypothesized that a non-invasive neuromuscular-machine interface providing real-time neurofeedback of individual motor units within a muscle could enable independent motor unit control to an extent suitable for high-performance BMI applications. Main results. Over 6 days of training, eight participants progressively learned to skillfully and independently control three biceps brachii motor units to complete a 2D center-out task. We show that neurofeedback enabled motor unit activity that largely violated recruitment constraints observed during ramp-and-hold isometric contractions thought to limit individual motor unit controllability. Finally, participants demonstrated the suitability of individual motor units for powering general applications through a spelling task. Significance. These results illustrate the flexibility of the sensorimotor system and highlight individual motor units as a promising source of control for BMI applications.