Mutations in N-ras predominate in acute myeloid leukemia.
Mutations in N-ras predominate in acute myeloid leukemia.
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N-ras 突变在急性髓系白血病中占主导地位。
DOI：
10.1182/blood.v69.4.1237.1237
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发表时间：
1987
期刊：
影响因子：
20.3
通讯作者：
LP Colly
中科院分区：
文献类型：
--
作者：
JL Bos;M. Verlaan;AJ van der Eb;JW Janssen;R. Delwel;B. Lowenberg;LP Colly
使用人工合成的寡聚体，我们研究了急性髓系白血病(AML)新鲜样本中ras癌基因突变的存在。我们最初的结果显示，8个样本中有5个包含N-ras基因第13密码子的突变。在随后对37个样本的研究中，我们只发现了一个N-ras-13突变，此外，还有4例N-ras基因61密码子突变和2例Ki-ras基因12密码子突变。未观察到ras基因扩增。我们得出结论，在大约20%到25%的AML病例中，存在突变的ras癌基因，主要是N-ras基因。突变的发生与白血病的细胞学特征无关。
Using synthetic oligomers we investigated fresh samples of acute myeloid leukemia (AML) for the presence of mutated ras oncogenes. Our original results showed that five of eight samples contained a mutation in codon 13 of the N-ras gene. In a subsequent study involving 37 samples, we found only one N-ras-13 mutation, and, in addition, mutations in codon 61 of the N-ras gene in four cases and a mutation in codon 12 of the Ki-ras gene in two cases. Amplification of ras genes was not observed. We conclude that in approximately 20% to 25% of AML cases, a mutated ras oncogene is present, predominantly the N-ras gene. The occurrence of mutations does not correlate with the cytological features of the leukemia.