Thoracic organ transplantation in the United States, 1995-2004
Thoracic organ transplantation in the United States, 1995-2004
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DOI：
10.1111/j.1600-6143.2006.01274.x
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发表时间：
2006-05-01
影响因子：
8.8
通讯作者：
Ardehali, A
中科院分区：
文献类型：
--
作者：
Orens, JB;Shearon, TH;Ardehali, A
本文回顾了1995年至2004年基于OPTN/SRTR数据的胸部器官移植趋势。等待心脏移植的患者人数继续下降，主要是因为有更少的冠状动脉疾病患者被列入移植名单。心脏移植的等待时间已经减少，等待名单上的死亡人数也有所下降，从1995年的每1000患者年259人下降到2004年的156人。与1995年相比，2004年进行的心脏移植较少，但调整后的患者生存率增加到1年88%和5年73%。肺气肿、特发性肺纤维化和囊性纤维化是2004年肺移植受者中最常见的适应症。1999年至2004年，肺移植的等待时间有所减少。2004年，等待名单上的死亡率下降到每1000病人年134例。在过去的十年中，移植后的一年生存率显著提高。在美国进行的心肺联合移植的数量仍然很低，2004年只有39例。心肺联合移植患者的1年和5年未校正生存率分别为58%和40%，低于单纯心肺移植患者。
This article reviews trends in thoracic organ transplantation based on OPTN/SRTR data from 1995 to 2004. The number of active waiting list patients for heart transplants continues to decline, primarily because there are fewer patients with coronary artery disease listed for transplantation. Waiting times for heart transplantation have decreased, and waiting list deaths also have declined, from 259 per 1000 patient-years at risk in 1995 to 156 in 2004. Fewer heart transplants were performed in 2004 than in 1995, but adjusted patient survival increased to 88% at 1 year and 73% at 5 years. Emphysema, idiopathic pulmonary fibrosis and cystic fibrosis were the most common indications among lung transplant recipients in 2004. Waiting time for lung transplantation decreased between 1999 and 2004. Waiting list mortality decreased to 134 per 1000 patient-years at risk in 2004. One-year survival following transplantation has improved significantly in the past decade. The number of combined heart-lung transplants performed in the United States remains low, with only 39 performed in 2004. Overall unadjusted survival, at 58% at 1 year and 40% at 5 years, is lower among heart-lung recipients than among either heart or lung recipients alone.