Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study.
Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study.
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术前血红蛋白、白蛋白、淋巴细胞和血小板联合检测对胃癌患者的预后意义：一项回顾性队列研究。
DOI：
10.18632/oncotarget.5629
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发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Hu JK
中科院分区：
文献类型：
--
作者：
Chen XL;Xue L;Wang W;Chen HN;Zhang WH;Liu K;Chen XZ;Yang K;Zhang B;Chen ZX;Chen JP;Zhou ZG;Hu JK
营养和免疫状态对胃癌（GC）患者的预后很重要。在此，我们评估了术前血红蛋白、白蛋白、淋巴细胞和血小板 (HALP) 组合对 GC 患者的预后意义。 2005年1月至2011年12月，1332例接受胃切除术的GC患者被X-tile按照样本量比例2:1随机分为训练集（n = 888）和验证集（n = 444）。 HALP 的切点为 56.8，随后两组患者均分为 HALP < 56.8 组和 HALP ≥ 56.8 组。多变量分析显示，在训练集和验证集中，性别（p < 0.001，p < 0.001）、肿瘤大小（p = 0.003，p = 0.035）和 T 分期（p < 0.001，p = 0.044）与 HALP 独立相关。 Kaplan-Meier（p < 0.001，p = 0.003）和Cox回归（p = 0.043，p = 0.042）显示两组HALP ≥ 56.8组的预后均显着优于HALP < 56.8组（p < 0.001，p < 0.001）。基于 HALP 的这两组列线图在预后预测方面比单独的 TNM 分期更准确。我们的研究结果表明，HALP 与临床病理特征密切相关，是 GC 患者的独立预后因素。基于HALP的列线图可以准确预测GC患者的预后。
Nutritional and immune status is important to the prognosis of patients with gastric carcinoma (GC). Here, we evaluated the prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) in patients with GC. From January 2005 to December 2011, 1332 patients with GC who underwent gastrectomy were randomly divided into the training (n = 888) and the validation sets (n = 444) by X-tile according to the sample size ratio 2:1. The cut-point of HALP was 56.8 and the patients were subsequently subdivided into HALP < 56.8 and HALP ≥ 56.8 groups in both two sets. Multivariate analysis revealed that gender (p < 0.001, p < 0.001), tumor size (p = 0.003, p = 0.035) and T stage (p < 0.001, p = 0.044) were independently related to HALP both in the training and the validation sets. Kaplan-Meier (p < 0.001, p = 0.003) and Cox regression (p = 0.043, p = 0.042) showed that the prognosis of HALP ≥ 56.8 group was significantly better than that of HALP < 56.8 group both in two sets (p < 0.001, p < 0.001). Nomograms of these two sets based on HALP was more accurate in prognostic prediction than TNM stage alone. Our findings suggested that HALP was closely associated with clinicopathological features and was an independent prognostic factor in GC patients. Nomogram based on HALP could accurately predict the prognosis of GC patients.