A biosensor based on magnetoresistance technology
A biosensor based on magnetoresistance technology
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DOI：
10.1016/s0956-5663(98)00037-2
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发表时间：
1998-10-01
影响因子：
12.6
通讯作者：
Colton, RJ
中科院分区：
文献类型：
--
作者：
Baselt, DR;Lee, GU;Colton, RJ
我们正在开发一种生物传感器，它将在单分子水平上测量将DNA-DNA、抗体-抗原或配体-受体对结合在一起的力。磁珠阵列计数器（BARC）将使用这些相互作用力将磁性微珠固定在固体基质上。微制造的磁阻传感器在基板上将指示是否珠被删除时，由磁力拉动。通过采用磁阻计算机存储器技术，可以在芯片上制造数百万个传感器并检测或筛选数千种分析物。这种便携式传感器的多分析物能力将是理想的现场测试，而直接测量分子间相互作用强度的潜力表明药物发现应用。(C)1998年Elsevier Science S.A. All rights reserved.
We are developing a biosensor that will measure, at the level of single molecules, the forces that bind DNA-DNA, antibody-antigen, or ligand-receptor pairs together. The Bead Array Counter (BARC) will use these interaction forces to hold magnetic microbeads to a solid substrate. Microfabricated magnetoresistive transducers on the substrate will indicate whether or not the beads are removed when pulled by magnetic forces. By adapting magnetoresistive computer memory technology, it may be possible to fabricate millions of transducers on a chip and detect or screen thousands of analytes. The multi-analyte capability of this portable sensor would be ideal for on-site testing, while the potential to directly gauge intermolecular interaction strengths suggests drug discovery applications. (C) 1998 Elsevier Science S.A. All rights reserved.