Estimating glutamate and Glx from GABA-optimized MEGA-PRESS: Off-resonance but not difference spectra values correspond to PRESS values
Estimating glutamate and Glx from GABA-optimized MEGA-PRESS: Off-resonance but not difference spectra values correspond to PRESS values
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DOI：
10.1016/j.pscychresns.2018.07.003
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发表时间：
2018-09-30
影响因子：
2.3
通讯作者：
Ragland, J. Daniel
中科院分区：
文献类型：
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作者：
Maddock, Richard J.;Caton, Michael D.;Ragland, J. Daniel
谷氨酸和GABA的质子磁共振波谱测量在神经精神病学研究中是重要的。一些研究设计需要同时测量两种代谢物。GABA测量需要专门的脉冲序列，最常见的方法是使用MEGA-PRESS进行J-差分光谱编辑。该方法实现了两种不同的策略，用于同时测量来自非共振或差异光谱的谷氨酸。然而，目前还不确定这两种策略与传统的谷氨酸测量相比如何。在这里，我们比较了这些方法在49名受试者（28名健康志愿者和21名首发精神病患者），其中PRESS（TE 80）和MEGA-PRESS（TE 68）光谱从背外侧前额叶皮层。谷氨酸和glx估计从MEGA-PRESS差异和非共振光谱进行了比较，谷氨酸和glx估计从PRESS光谱使用相关分析。在健康志愿者中，PRESS和MEGA-PRESS非共振值之间的相关性为r >= 0.88，并且显著高于PRESS和MEGA-PRESS差谱值之间的相关性（r
Proton magnetic resonance spectroscopy measurements of glutamate and GABA are important in neuropsychiatric research. Some study designs require simultaneous measurement of both metabolites. GABA measurement requires specialized pulse sequences, the most common approach being J-difference spectral editing with MEGA-PRESS. This method enables two different strategies for concurrently measuring glutamate from either off-resonance or difference spectra. However, it is uncertain how either strategy compares to conventional glutamate measurements. Here we compared these approaches in 49 subjects (28 healthy volunteers and 21 first-episode psychosis patients), in whom both PRESS (TE 80) and MEGA-PRESS (TE 68) spectra were obtained from dorsolateral prefrontal cortex. Glutamate and glx estimates from MEGA-PRESS difference and off-resonance spectra were compared to glutamate and glx estimates from PRESS spectra using correlational analyses. In healthy volunteers, correlations between PRESS and MEGA-PRESS off-resonance values were r >= 0.88 and were significantly higher than correlations between PRESS and MEGA-PRESS difference spectrum values (r