AGE-RELATED-CHANGES IN IMMUNOGLOBULIN ISOTYPES IN WHOLE AND PAROTID-SALIVA AND SERUM IN HEALTHY-INDIVIDUALS
AGE-RELATED-CHANGES IN IMMUNOGLOBULIN ISOTYPES IN WHOLE AND PAROTID-SALIVA AND SERUM IN HEALTHY-INDIVIDUALS
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DOI：
10.1111/j.1399-302x.1995.tb00143.x
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发表时间：
1995-08-01
影响因子：
--
通讯作者：
MARSH, PD
中科院分区：
文献类型：
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作者：
CHALLACOMBE, SJ;PERCIVAL, RS;MARSH, PD
粘膜感染占老年人感染的大多数，但很少知道粘膜免疫力是否随着年龄的增长而下降。本研究的目的是探讨年龄对健康成人唾液和血清免疫球蛋白水平及唾液免疫球蛋白分泌率的影响。健康受试者共116人，分为以下年龄组：20-39岁；40岁至59岁;60-79年和80年。收集所有受试者未受刺激（静息）的完整腮腺和受刺激的腮腺唾液及血清。用酶联免疫吸附捕获法测定唾液和血清免疫球蛋白。血清免疫球蛋白G （IgG）和IgM水平在老年组显著降低，而IgA水平随年龄无显著降低。年龄最大的D组全唾液中IgG和IgA水平明显升高，而IgM水平未见变化。腮腺唾液中免疫球蛋白水平未见明显变化。然而，在年龄最大的年龄组中，全唾液中IgA和IgM的分泌率明显下降，而IgG的分泌率没有明显下降。腮腺唾液分泌率随年龄变化不明显。我们的研究结果表明，随着年龄的增长，唾液中免疫球蛋白分泌率和循环免疫球蛋白浓度下降，这可能与老年人对传染病的易感性增加有关。
Mucosal infections account for the majority of infections seen in elderly people, but little is known of whether mucosal immunity decrease with age. The objective of this study was to investigate the effect of age on the levels of salivary and serum immunoglobulins and the salivary immunoglobulin secretion rates in a healthy adult population. Healthy subjects (116 total) were divided into the following age groups: 20-39; 40-59; 60-79 and >80 years. Unstimulated (resting) whole and stimulated parotid saliva and serum were collected from all participants. Salivary and serum immunoglobulins were quantified by enzyme-linked immunosorbent capture assays. The levels of serum immunoglobulin G (IgG) and IgM were significantly reduced in the oldest age group, whereas no significant reduction in the level of IgA with age was observed. The IgG and IgA levels in whole saliva increased significantly in the oldest age group D, but no changes were detected in IgM levels. No significant changes in any immunoglobulin levels with age were found in parotid saliva. However, significant reductions in the secretion rates of IgA and IgM, but not IgG, in whole saliva were detected in the oldest age group. No significant changes in the secretion rates in parotid saliva were found with age, Our results demonstrate a decline in immunoglobulin secretion rates in saliva and in circulating immunoglobulin concentrations with increased age, which may contribute to the increased susceptibility of elderly individuals to infectious diseases.