Regioselective C-H functionalization directed by a removable carboxyl group: Palladium-catalyzed vinylation at the unusual position of indole and related heteroaromatic rings
Regioselective C-H functionalization directed by a removable carboxyl group: Palladium-catalyzed vinylation at the unusual position of indole and related heteroaromatic rings
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DOI：
10.1021/ol8000602
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发表时间：
2008-03-20
期刊：
影响因子：
5.2
通讯作者：
Miura, Masahiro
中科院分区：
文献类型：
--
作者：
Maehara, Atsushi;Tsurugi, Hayato;Miura, Masahiro
钯催化的吲哚-3-羧酸与烯烃的氧化乙烯基化反应通过直接的C-H官能化和脱羧基反应有效地进行，生成相应的2-乙烯基吲哚。类似地，吡咯、呋喃和噻吩甲酸也进行脱羧化乙烯基化反应。
The palladium-catalyzed oxidative vinylation of indole-3-carboxylic acids with alkenes effectively proceeds via directed C-H functionalization and decarboxylation to produce the corresponding 2-vinylated indoles. Similarly, pyrrole-, furan-, and thiophenecarboxylic acids also undergo decarboxylative vinylation.