Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands
Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands
复制标题
手性烯烃-膦配体钯催化吲哚和吡咯的不对称烯丙基烷基化
DOI：
10.1021/ol200602x
复制
发表时间：
2011-05-06
期刊：
影响因子：
5.2
通讯作者：
Du, Haifeng
中科院分区：
文献类型：
--
作者：
Cao, Ziping;Liu, Yilin;Du, Haifeng
以（S）-BINOL为起始原料，经四步反应合成了一系列手性联萘基末端烯膦杂化配体，并将其用于钯催化的吲哚和吡咯的烯丙基烷基化反应，以高产率和良好的ee's得到目标产物.
A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee's.