Modulation of colonization by black-pigmented Bacteroides species in squirrel monkeys by immunization with Bacteroides gingivalis.
Modulation of colonization by black-pigmented Bacteroides species in squirrel monkeys by immunization with Bacteroides gingivalis.
复制标题
通过牙龈拟杆菌免疫调节松鼠猴中黑色拟杆菌的定植。
DOI：
10.1128/iai.57.8.2313-2317.1989
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
Clark,WB
中科院分区：
文献类型：
--
作者：
McArthur,WP;Magnusson,I;Marks,RG;Clark,WB
牙周病是一种炎症反应，被认为是由在牙周缝隙中定植的特定微生物引发的。从理论上讲，如果不允许病原菌在龈下定植，牙周病是可以预防的。体液免疫反应是调节细菌在牙周缝隙定植的机制之一。为探讨全身体液免疫对细菌在龈下定植的影响，用黑色素拟杆菌(Bacteroids Gigivalis)免疫松猴。和可能的牙周病原体。在用浸透细菌的缝线材料结扎一个象限的五颗牙齿并将其分布在整个牙龈边缘的过程中，免疫和假免疫的猴子被口服接种10(10)个活的牙龈假单胞菌。免疫后，免疫球蛋白G抗B抗体水平升高。血清中的牙周炎，与黑色素类杆菌在牙龈缝隙的定植显著减少的强烈趋势有关。
Periodontal diseases are inflammatory responses thought to be triggered by specific microorganisms colonizing in the gingival crevice. Theoretically, periodontal diseases could be prevented if the etiologic organisms were not allowed to colonize the subgingival area. The humoral immune response is one mechanism which may modulate bacterial colonization in the gingival crevice. To test the effect of systemic humoral immunity on subgingival colonization by bacteria, squirrel monkeys (Saimiri sciureus) were immunized with Bacteroides gingivalis, a black-pigmented Bacteroides sp. and putative periodontal pathogen. Immunized and sham-immunized monkeys were orally inoculated with 10(10) viable B. gingivalis during ligation of five teeth in one quadrant with bacterium-soaked suture material and distribution over the entire dentogingival margin. Immunization resulted in an increased level of immunoglobulin G anti-B. gingivalis in serum and was associated with a strong trend toward a statistically significant reduction in colonization of the gingival crevice by black-pigmented bacteroides.