Drosophila as a model for ageing
Drosophila as a model for ageing
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DOI：
10.1016/j.bbadis.2017.09.016
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发表时间：
2018-09-01
影响因子：
6.2
通讯作者：
Partridge, Linda
中科院分区：
文献类型：
--
作者：
Piper, Matthew D. W.;Partridge, Linda
黑腹果蝇一直是发展我们目前对衰老分子机制的理解的关键模型。特别值得注意的是，它在建立胰岛素和IGF-1样信号减少的进化保守性方面的作用，以促进健康的老龄化。利用其许多优势进行实验，最近的工作揭示了精确的营养和遗传干预如何提高苍蝇寿命，而不会产生明显的有害副作用。我们简要总结了这些最近的发现，以及它们如何通过肠道和肌肉中的作用来改变衰老的例子。这些发现强调了如何扩大我们对代谢和信号相互联系的理解，将为如何利用这些益处进行抗衰老干预提供更深入的了解。
Drosophila melanogaster has been a key model in developing our current understanding of the molecular mechanisms of ageing. Of particular note is its role in establishing the evolutionary conservation of reduced insulin and IGF-1-like signaling in promoting healthy ageing. Capitalizing on its many advantages for experimentation, more recent work has revealed how precise nutritional and genetic interventions can improve fly lifespan without obvious detrimental side effects. We give a brief summary of these recent findings as well as examples of how they may modify ageing via actions in the gut and muscle. These discoveries highlight how expanding our understanding of metabolic and signaling interconnections will provide even greater insight into how these benefits may be harnessed for anti-ageing interventions.