Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: Quality and analysis results of a phase I trial
Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: Quality and analysis results of a phase I trial
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DOI：
10.1002/jmri.20202
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发表时间：
2004-12-01
影响因子：
4.4
通讯作者：
Nabors, LB
中科院分区：
文献类型：
--
作者：
Akella, NS;Twieg, DB;Nabors, LB
目的：为了确定阈值的质量T2* 加权灌注磁共振成像（MRI）的研究和评估血管生成抑制剂对相对血液低和体积变化的脑肿瘤患者在多institutionssetting.Materials和方法的影响：共36名志愿者从四个参与机构临床诊断为恶性胶质瘤进行了研究，使用灌注MRI协议。这些研究包括基线研究和每八周一次的随访研究，以评估抗血管生成剂对肿瘤灌注的影响。通过定义验收的统计阈值，对灌注成像数据进行质量测试。对肿瘤进行感兴趣区域（ROI）分析，并将动力学参数相对于正常tissue.Results进行归一化：计算了我们的数据集的γ变量拟合优度、T2* 恢复和平均信号半最小全宽（FWHMin）的统计阈值，单侧置信区间为99%;分别为6.91%、79.48%和23.35秒。在记录临床responsibility.Conclusion：恶性脑肿瘤有改变灌注参数，可用于了解和监测新血管形成的患者中观察到的血容量和流量测量的减少。这允许对血管生成抑制药物的功效进行非侵入性评估。(C)2004 Wiley-Liss，Inc.
Purpose: To determine thresholds of quality for a T2*-weighted perfusion magnetic resonance imaging (MRI) study and evaluate the effects of an angiogenesis inhibitor on relative blood low and volume changes in brain tumor patients in a multi-institution setting.Materials and Methods: A total of 36 volunteers from four participating institutions with clinically diagnosed malignant gliomas were studied using perfusion MRI protocols. These included a baseline study, and follow-up studies every eight weeks to evaluate the effect of an anti-angiogenic agent on tumor perfusion. Quality tests were performed on the perfusion imaging data by defining statistical thresholds of acceptance. Region of interest (ROI) analysis was performed on tumors and kinetic parameters were normalized with respect to normal tissue.Results: Statistical thresholds for goodness of the gamma variate fit, T2* recovery, and mean signal full-width half-minimum (FWHMin) were computed for our data sets with a 99% one-sided confidence interval; these were 6.91%, 79.48%, and 23.35 seconds, respectively. Decreases in-blood volume and flow measurements were observed in patients with documented clinical response.Conclusion: Malignant brain tumors have altered perfusion parameters that may be used to understand and monitor neovascularization. This permits non-invasive assessment of the efficacy of angiogenesis inhibiting drugs. (C) 2004 Wiley-Liss, Inc.