Macular pigment spatial distribution effects on glare disability.
Macular pigment spatial distribution effects on glare disability.
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DOI：
10.1016/j.optom.2014.12.004
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发表时间：
2015-10-01
影响因子：
2.3
通讯作者：
Bassi, Carl J
中科院分区：
文献类型：
--
作者：
Putnam, Christopher M;Bassi, Carl J
目得：方法：采用自行设计的黄斑色素光密度（macular pigment optical density，MPOD）测量装置，在0°、2°、4°、6°和8°偏心距下，测量视网膜中央16°沿着4个半径的MPOD。在所有测量的视网膜位点测量MPOD为离散值和积分值。GD计算为无眩光和眩光条件之间的对比敏感度（CS）的差异，使用相同的刺激在相同的偏心率。GD定义为[（CSNo眩光-CSNo眩光）/CSNo眩光]，以便通过控制受试者样本中的CS变异性来隔离MPOD的眩光衰减效应。的离散和集成的MPOD与GD的相关性进行了compared.RESULTS：cHFP确定可靠的MPOD空间分布图，表现出一阶指数衰减作为增加偏心率的函数。有一个显着的负相关性之间的测量中心凹MPOD和GD使用6个周期每度（CPD）和9个CPD刺激。显着相关性被发现之间的相应paraferialMPOD措施和GD在2 °和4°偏心使用9 CPD刺激与更大的MPOD与眩光disability.CONCLUSIONS：这些结果是一致的眩光衰减MP在更高的空间频率的影响，并支持这一假设，即离散和综合措施的MPOD有类似的相关性与眩光衰减效应在整个黄斑。此外，中央凹MPOD峰值似乎影响整个黄斑的GD。
PURPOSE: This project explored the relationship of the macular pigment optical density (MPOD) spatial profile with measures of glare disability (GD) across the macula.METHODS: A novel device was used to measure MPOD across the central 16° of retina along four radii using customized heterochromatic flicker photometry (cHFP)at eccentricities of 0°, 2°, 4°, 6° and 8°. MPOD was measured as discrete and integrated values at all measured retinal loci. GD was calculated as a difference in contrast sensitivity (CS) between no glare and glare conditions using identical stimuli presented at the same eccentricities. GD was defined as [(CSNo Glare-CSGlare)/CSNo Glare] in order to isolate the glare attenuation effects of MPOD by controlling for CS variability among the subject sample. Correlations of the discrete and integrated MPOD with GD were compared.RESULTS: The cHFP identified reliable MPOD spatial distribution maps demonstrating a 1st-order exponential decay as a function of increasing eccentricity. There was a significant negative correlation between both measures of foveal MPOD and GD using 6 cycles per degree (cpd) and 9 cpd stimuli. Significant correlations were found between corresponding parafoveal MPOD measures and GD at 2 and 4° of eccentricity using 9 cpd stimuli with greater MPOD associated with less glare disability.CONCLUSIONS: These results are consistent with the glare attenuation effects of MP at higher spatial frequencies and support the hypothesis that discrete and integrated measures of MPOD have similar correlations with glare attenuation effects across the macula. Additionally, peak foveal MPOD appears to influence GD across the macula.