Trends and challenges of multi-drug resistance in childhood tuberculosis.
Trends and challenges of multi-drug resistance in childhood tuberculosis.
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DOI：
10.3389/fcimb.2023.1183590
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
Drug-resistant tuberculosis (DR-TB) in children is a growing global health concern, This review provides an overview of the current epidemiology of childhood TB and DR-TB, including prevalence, incidence, and mortality. We discuss the challenges in diagnosing TB and DR-TB in children and the limitations of current diagnostic tools. We summarize the challenges associated with treating multi-drug resistance TB in childhood, including limitations of current treatment options, drug adverse effects, prolonged regimens, and managing and monitoring during treatment. We highlight the urgent need for improved diagnosis and treatment of DR-TB in children. The treatment of children with multidrug-resistant tuberculosis will be expanded to include the evaluation of new drugs or new combinations of drugs. Basic research is needed to support the technological development of biomarkers to assess the phase of therapy, as well as the urgent need for improved diagnostic and treatment options.
DOI：
10.1183/09031936.00187711
发表时间：
2012-08
期刊：
The European respiratory journal
影响因子：
--
作者：
Sandgren A;Cuevas LE;Dara M;Gie RP;Grzemska M;Hawkridge A;Hesseling AC;Kampmann B;Lienhardt C;Manissero D;Wingfield C;Graham SM
通讯作者：
Graham SM
影响因子：
4.6
作者：
Comella-Del-Barrio P;Izquierdo-Garcia JL;Gautier J;Doresca MJC;Campos-Olivas R;Santiveri CM;Muriel-Moreno B;Prat-Aymerich C;Abellana R;Pérez-Porcuna TM;Cuevas LE;Ruiz-Cabello J;Domínguez J
通讯作者：
Domínguez J