Molecular connections between circadian clock and health/ageing
Molecular connections between circadian clock and health/ageing
复制标题
生物钟与健康/衰老之间的分子联系
DOI：
10.1093/jb/mvac028
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fukada Yoshitaka
中科院分区：
文献类型：
--
作者：
Nakahata Yasukazu;Fukada Yoshitaka
几十年来，人们为解决疾病发展的分子机制付出了相当大的努力。解决这个问题的一个重要线索是生物钟。最近的发现揭示了以前未知的生物钟和疾病发病率之间的分子联系，从而导致衰老过程。此外，时间疗法正在成为一种新的概念，它根据靶基因的表达来优化一天中的给药时间，以最大限度地提高疗效并将副作用降至最低。这一概念将有助于治愈患者，防止他们遭受不可避免的疼痛和副作用。这期JB特刊《生物钟与健康/衰老之间的分子联系》讨论了生物钟如何从分子水平到生物水平与健康和衰老联系在一起。
For decades, considerable efforts have been expended for solving the molecular mechanisms of disease progression. An important clue to tackle this question is the circadian clock. Recent findings have uncovered previously unknown molecular connections between circadian clock and disease incidence, consequently causing the ageing process. Furthermore, ‘chronotherapy’ is emerging as a new concept of optimizing the time of the day for drug administration according to target gene expressions in order to maximize therapeutic efficacy and minimize the side effects. This concept will help cure patients and prevent them from suffering evitable pain and side effects. This JB special issue ‘Molecular connections between circadian clock and health/aging’ discusses how the circadian clocks link to health and ageing from molecular to organismal levels.