Oscillatory brain activity and transcranial direct current stimulation in humans
Oscillatory brain activity and transcranial direct current stimulation in humans
复制标题
DOI：
10.1097/01.wnr.0000127460.08361.84
复制
发表时间：
2004-06-07
期刊：
影响因子：
1.7
通讯作者：
Paulus, W
中科院分区：
文献类型：
--
作者：
Antal, A;Varga, ET;Paulus, W
本研究的目的是诱导健康人受试者的视觉皮层的振荡活动的变化，通过调制神经元的兴奋性，使用弱经颅直流电刺激（tDCS）。tDCS是一种非侵入性刺激方法，其诱导皮层兴奋性的延长的极性依赖性增加或减少。β和γ频率范围内的高频振荡活动的增加在时间上与初级视觉诱发电位（VEP）的N70峰密切相关，初级视觉诱发电位是视觉激活的早期感觉成分。因此，该电位可用于观察与振荡活性相关的tDCS诱导的变化。在10 min阳极或阴极刺激前、刺激后即刻和刺激结束后10、20、30 min，采用正弦亮度光栅以开/关模式记录VEP。阴极刺激显著降低，而阳极刺激略微增加了标准化的β和γ频率功率。我们在这里已经表明，tDCS短暂和可逆地改变了视觉刺激引起的组织皮层活动。由于伽马活动也与更高水平的信息处理有关，因此tDCS可能是影响高阶认知过程的合适方法。
The aim of this study was to induce changes of the oscillatory activity in the visual cortex of healthy human subjects by modulation of neuronal excitability using weak transcranial direct current stimulation (tDCS). tDCS is a non-invasive stimulation method which induces prolonged, polarity-dependent increases or reductions in cortical excitability. An increase in high frequency oscillatory activity in the beta and gamma frequency ranges is closely related in time to the N70 peak of the primary visual evoked potential (VEP), which is an early sensory component of visual activation. Therefore this potential can be used to observe tDCS-induced changes related to oscillatory activity. VEPs were recorded using sinusoidal luminance gratings in an on/off mode before, immediately after and 10, 20, 30 min after the end of 10 min anodal or cathodal stimulation. Cathodal stimulation significantly decreased while anodal stimulation slightly increased the normalized beta and gamma frequency powers. We have shown here that tDCS transiently and reversibly changed the organized cortical activity elicited by visual stimulation. Since gamma activity is also related to a higher level of information processing, tDCS might be a suitable method to affect higher order cognitive processes.