Aortic and Hepatic Contrast Enhancement During Hepatic-Arterial and Portal Venous Phase Computed Tomography Scanning: Multivariate Linear Regression Analysis Using Age, Sex, Total Body Weight, Height, and Cardiac Output
Aortic and Hepatic Contrast Enhancement During Hepatic-Arterial and Portal Venous Phase Computed Tomography Scanning: Multivariate Linear Regression Analysis Using Age, Sex, Total Body Weight, Height, and Cardiac Output
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DOI：
10.1097/rct.0000000000000513
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发表时间：
2017-03-01
影响因子：
1.3
通讯作者：
Awai, Kazuo
中科院分区：
文献类型：
--
作者：
Masuda, Takanori;Nakaura, Takeshi;Awai, Kazuo
目的：我们评估了年龄，性别，总体重（TBW），身高（HT）和心输出量（CO）的患者对主动脉和肝脏对比增强在肝动脉期（HAP）和门静脉期（PVP）计算机断层扫描（CT）scanning.Methods：这项前瞻性研究得到了机构审查委员会的批准，事先知情同意参加所有168例患者。所有患者均采用我们的常规方案进行检查;造影剂为600 mg/kg碘。在开始CT扫描后5分钟内用便携式电子速度计测量心输出量。我们计算了HAP期间腹主动脉和PVP期间肝实质的对比增强（每克碘：.HU/gI）。结果：HU/gI值与年龄、性别、TBW、HT、CO之间存在显著相关性（P均< 0.001），HU/gI值与年龄、性别、TBW、HT、CO之间无显著相关性（P> 0.05）。多元线性回归分析显示，只有TBW和CO是独立的预测值（P < 0.001）。结论：多因素线性回归分析显示，只有TBW和CO与主动脉和肝实质增强显著相关，而年龄、性别和HT与主动脉和肝实质增强无关。当根据TBW调整方案时，CO是影响肝脏CT主动脉和肝脏实质增强的唯一独立因素。
Objective: We evaluated the effect of the age, sex, total body weight (TBW), height (HT) and cardiac output (CO) of patients on aortic and hepatic contrast enhancement during hepatic-arterial phase (HAP) and portal venous phase (PVP) computed tomography (CT) scanning.Methods: This prospective study received institutional review board approval; prior informed consent to participate was obtained from all 168 patients. All were examined using our routine protocol; the contrast material was 600 mg/kg iodine. Cardiac output was measured with a portable electrical velocimeter within 5 minutes of starting the CT scan. We calculated contrast enhancement (per gram of iodine:.HU/gI) of the abdominal aorta during the HAP and of the liver parenchyma during the PVP. We performed univariate and multivariate linear regression analysis between all patient characteristics and the.HU/gI of aortic-and liver parenchymal enhancement.Results: Univariate linear regression analysis demonstrated statistically significant correlations between the.HU/gI and the age, sex, TBW, HT, and CO (all P < 0.001). However, multivariate linear regression analysis showed that only the TBWand CO were of independent predictive value (P < 0.001). Also, only the CO was independently and negatively related to aortic enhancement during HAP and to liver parenchymal enhancement when the contrast material injection protocol was adjusted for the TBW (P < 0.001).Conclusion: By multivariate linear regression analysis only the TBW and CO were significantly correlated with aortic and liver parenchymal enhancement; the age, sex, and HTwere not. The CO was the only independent factor affecting aortic and liver parenchymal enhancement at hepatic CTwhen the protocol was adjusted for the TBW.