REVERSAL OF FENTANYL FLUANISONE NEUROLEPTANALGESIA IN THE RABBIT USING MIXED AGONIST ANTAGONIST OPIOIDS
REVERSAL OF FENTANYL FLUANISONE NEUROLEPTANALGESIA IN THE RABBIT USING MIXED AGONIST ANTAGONIST OPIOIDS
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DOI：
10.1258/002367789780863655
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发表时间：
1989-04-01
影响因子：
2.4
通讯作者：
WOOTTON, R
中科院分区：
文献类型：
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作者：
FLECKNELL, PA;LILES, JH;WOOTTON, R
已在兔中研究了使用混合激动剂/拮抗剂阿片类药物的芬太尼/氟阿尼松的神经安定镇痛剂组合的逆转。研究的所有化合物（纳洛酮、纳布啡、美普他酚、布托啡诺、丁丙诺啡、喷他佐辛、多沙普仑）均可逆转芬太尼/氟阿尼松产生的呼吸抑制和镇静作用。芬太尼/氟阿尼松镇痛作用持续180 min，可被纳洛酮迅速完全拮抗。混合激动剂/拮抗剂阿片类药物产生的镇痛程度降低，但与纳洛酮相反，镇痛活性持续120分钟（美普他酚）至420分钟（丁丙诺啡）。对芬太尼/氟阿尼松和咪达唑仑麻醉的家兔给予丁丙诺啡证实，呼吸抑制的逆转伴随着动脉pH值、PCO 2和PCO 2恢复至麻醉前值。使用神经阻滞剂镇痛麻醉方案，已被证明可提供有效的手术麻醉，结合使用混合激动剂/拮抗剂阿片类药物提供术后镇痛的逆转，似乎是当前实验室动物麻醉实践的一种有价值的改进。
The reversal of the neuroleptanalagesic combination of fentanyl/fluanisone using mixed agonist/antagonist opioids has been investigated in the rabbit. All of the compounds studied (naloxone, nalbuphine, meptazinol, butorphanol, buprenorphine, pentazocine, doxapram) reversed the respiratory depression and sedation produced by fentanyl/fluanisone. Fentanyl/fluanisone produced profound analgesia for 180 min, which was rapidly and completely antagonized by naloxone. The mixed agonist/antagonist opioids produced a reduction in the degree of analgesia but, in contrast to naloxone, analgesic activity persisted from 120 min (meptazinol) to 420 min (buprenorphine). Administration of buprenorphine to rabbits anaesthetized with fentanyl/fluanisone and midazolam confirmed that the reversal of respiratory depression was accompanied by the return of arterial pH, PCO2 and PCO2 to preanaesthetic values. The use of neuroleptanalgesic anaesthetic regimens, which have have been shown to provide effective surgical anaesthesia, combined with reversal using a mixed agonist/antagonist opioid to provide postoperative analgesia, appears to be a valuable refinement of current laboratory animal anaesthetic practice.