Distinguishing Between Mouse and Human Pluripotent Stem Cell Regulation: The Best Laid Plans of Mice and Men
Distinguishing Between Mouse and Human Pluripotent Stem Cell Regulation: The Best Laid Plans of Mice and Men
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DOI：
10.1002/stem.298
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发表时间：
2010-03-31
期刊：
影响因子：
5.2
通讯作者：
Bhatia, Mickie
中科院分区：
文献类型：
--
作者：
Schnerch, Angelique;Cerdan, Chantal;Bhatia, Mickie
多能干细胞（PSCs）来源于小鼠和人类的胚胎，是PSCs的两个主要来源。这些细胞普遍由其发育特性定义，特别是其自我更新能力和分化潜力，其在小鼠和人类中由保守转录因子协调的复杂转录网络调节。然而，控制小鼠和人PSC自我更新和谱系发育的转录网络和信号通路存在显着差异。为了区分普遍适用的和物种特异性的特征，我们整理和比较了小鼠和人类PSC的分子和细胞描述。在这里，我们比较和对比了小鼠和人类PSC的转录组和表观基因组所决定的信号的反应，这将有望成为该领域的关键资源。这些分析强调了在设计利用人类PSC临床潜力的策略时考虑物种差异的重要性。干细胞2010; 28：419-430
Pluripotent stem cells (PSCs) have been derived from the embryos of mice and humans, representing the two major sources of PSCs. These cells are universally defined by their developmental properties, specifically their self-renewal capacity and differentiation potential which are regulated in mice and humans by complex transcriptional networks orchestrated by conserved transcription factors. However, significant differences exist in the transcriptional networks and signaling pathways that control mouse and human PSC self-renewal and lineage development. To distinguish between universally applicable and species-specific features, we collated and compared the molecular and cellular descriptions of mouse and human PSCs. Here we compare and contrast the response to signals dictated by the transcriptome and epigenome of mouse and human PSCs that will hopefully act as a critical resource to the field. These analyses underscore the importance of accounting for species differences when designing strategies to capitalize on the clinical potential of human PSCs. STEM CELLS 2010; 28: 419-430