The multiple roles of myelin protein genes during the development of the oligodendrocyte.
The multiple roles of myelin protein genes during the development of the oligodendrocyte.
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DOI：
10.1042/an20090051
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发表时间：
2010-02-01
期刊：
影响因子：
4.7
通讯作者：
Campagnoni AT
中科院分区：
文献类型：
--
作者：
Fulton D;Paez PM;Campagnoni AT
已经清楚的是，最早鉴定的几种髓鞘蛋白基因的产物执行延伸到髓鞘之外的功能。有趣的是，这些髓鞘蛋白，包括蛋白脂质蛋白，2′，3 ′-环核苷酸3′-磷酸二酯酶和经典和golli髓鞘碱性蛋白（MBP），在少突胶质细胞发育的不同阶段发挥重要作用。这些非髓鞘相关的功能是多种多样的，包括在过程生长，迁移，RNA运输，少突胶质细胞存活和离子通道调节的调节作用。然而，尽管由不同的髓鞘基因执行各种各样的细胞功能，它们实现这些许多功能的途径似乎会聚在一个共同的机制，涉及Ca 2+调节，细胞骨架重排和信号转导。在本综述中，这些髓鞘蛋白的新出现的功能将被描述，这些将在其对少突胶质细胞发育的贡献的背景下进行讨论。
It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′,3′-cyclic nucleotide 3′-phosphodiesterase and the classic and golli MBPs (myelin basic proteins), play important roles during different stages of oligodendroglial development. These non-myelin-related functions are varied and include roles in the regulation of process outgrowth, migration, RNA transport, oligodendrocyte survival and ion channel modulation. However, despite the wide variety of cellular functions performed by the different myelin genes, the route by which they achieve these many functions seems to converge upon a common mechanism involving Ca2+ regulation, cytoskeletal rearrangements and signal transduction. In the present review, the newly emerging functions of these myelin proteins will be described, and these will then be discussed in the context of their contribution to oligodendroglial development.