The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior
The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior
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DOI：
10.1080/15257770802143988
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发表时间：
2008-01-01
影响因子：
1.3
通讯作者：
Peters, G. J.
中科院分区：
文献类型：
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作者：
Bijnsdorp, I. V.;de Bruin, M.;Peters, G. J.
血小板源性内皮细胞生长因子 (PD-ECGF) 与嘧啶酶胸苷磷酸化酶 (TP) 相似。肿瘤部位的高 TP 表达与肿瘤生长、血管生成诱导和转移相关。因此，高 TP 很可能与不良预后相关。 TP不仅在肿瘤细胞中表达，也在肿瘤周围组织中表达，例如肿瘤浸润巨噬细胞。 TP 催化胸苷转化为胸腺嘧啶和多氧核糖-1-磷酸 (dR-1-P)。后者以其母体形式或其糖形式脱氧核糖（dR）可能在诱导血管生成中发挥作用。它可以调节细胞能量代谢或作为产生活性氧的化学反应的底物。 L-脱氧核糖 (L-dR) 和胸苷磷酸化酶抑制剂 (TPI) 可以逆转这些影响。 TP诱导的机制尚不完全清楚，但TNF、IL10等细胞因子已明确显示可诱导其表达。 TP 的各种复杂相互作用使其在细胞功能中发挥重要作用，因此是癌症治疗的理想靶点。
Platelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high TP expression at tumor sites is correlated with tumor growth, induction of angiogenesis, and metastasis. Therefore, high TP is most likely associated with a poor prognosis. TP is not only expressed in tumor cells but also in tumor surrounding tissues, such as tumor infiltrating macrophages. TP catalyzes the conversion of thymidine to thymine and doxyribose-1-phosphate (dR-1-P). The latter in its parent form or in its sugar form, deoxyribose (dR) may play a role in the induction of angiogenesis. It may modulate cellular energy metabolism or be a substrate in a chemical reaction generating reactive oxygen species. L-deoxyribose (L-dR) and thymidine phosphorylase inhibitor (TPI) can reverse these effects. The mechanism of TP induction is not yet completely clear, but TNF, IL10 and other cytokines have been clearly shown to induce its expression. The various complex interactions of TP give it an essential role in cellular functioning and, hence, it is an ideal target in cancer therapy.