Behavioral tests as indicator for pain and distress in a primate endometriosis model
Behavioral tests as indicator for pain and distress in a primate endometriosis model
复制标题
DOI：
10.1111/j.1600-0684.2011.00496.x
复制
发表时间：
2011-10-01
影响因子：
0.7
通讯作者：
Einspanier, A.
中科院分区：
文献类型：
--
作者：
Arnold, C.;Lamp, J.;Einspanier, A.
背景普通绒猴（Callithrix jacchus）是常用的实验动物，需要灵敏的测试系统来评估由手术和疾病引起的损伤和疼痛。使用录像、威斯康星州通用测试装置（WGTA）和食物树研究了患有子宫内膜异位症的绒猴和健康猴之间的社会行为和认知技能差异。结果绒猴表现出主要为三模式的活动过程。在患有子宫内膜异位症的动物中，社会梳理和活动显著减少;此外，患病的猴子对认知测试设置的习惯明显更差。结论录像法和WGTA法是检测普通绒猴疾病相关性损伤的有效方法，对实验的进一步完善具有重要意义。
Background As common marmosets (Callithrix jacchus) are frequently used experimental animals, sensitive test systems are needed to evaluate impairment and pain caused by procedures and diseases.Methods A diurnal profile of healthy animals was obtained by videotaping. Differences in social behavior and cognitive skills between marmosets with established endometriosis and healthy monkeys were investigated using the videotaping, the Wisconsin General Test Apparatus (WGTA), and a food tree.Results The marmosets showed a mostly trimodal course of activity. Social grooming and activity were significantly decreased in animals with endometriosis; furthermore, the diseased monkeys habituated significantly worse to the cognitive test settings. The food tree experiments offered no differences between diseased and control animals.Conclusion The videotaping and the WGTA are suitable methods to detect disease-related impairments in common marmosets, which is essential for the refinement of experiments.