Effect of acute ethanol and acute allopregnanolone on spatial memory in adolescent and adult rats
Effect of acute ethanol and acute allopregnanolone on spatial memory in adolescent and adult rats
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DOI：
10.1016/j.alcohol.2011.03.001
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发表时间：
2011-08-01
期刊：
影响因子：
2.3
通讯作者：
Matthews, Douglas B.
中科院分区：
文献类型：
--
作者：
Chin, Vivien S.;Van Skike, Candice E.;Matthews, Douglas B.
酒精对青春期和成年大鼠的影响在许多方面有所不同。酒精对青少年和成年人空间记忆的影响的证据是模棱两可的。青少年对酒精所致的空间记忆获得的损害是更敏感还是更不敏感目前还不清楚；关于急性酒精对空间记忆提取的影响，几乎没有任何年龄差异的研究。因此，我们研究了急性乙醇对青少年和成人Morris水迷宫中空间记忆的影响。别孕酮(allopregnanolone，ALLO)是GABA(A)受体的调节剂，其行为效应与乙醇相似。我们还试图确定别孕酮对青少年和成年人空间记忆的影响。成年(PN70-72)和青春期(28-30)雄性大鼠在Morris水迷宫中训练6d，第7天给予急性剂量的乙醇(生理盐水，1.5和2.0g/kg)或Allo(车用，9和18 mg/kg)。第8天进行探测试验。然而，在酒精和ALLO条件下，青少年和成年人都有类似的空间记忆障碍。目前的结果表明，乙醇和Allo都会损害海马依赖的空间记忆，无论年龄大小，因为一旦学习发生，乙醇或Allo不会对青少年和成年人的空间记忆提取造成不同的损害。考虑到酒精对青春期大鼠认知的影响的结果喜忧参半，还需要进一步的研究来确定对已报道的不同结果至关重要的因素。(C)2011 Elsevier Inc.保留所有权利。
The effects of ethanol differ in adolescent and adult rats on a number of measures. The evidence of the effects of ethanol on spatial memory in adolescents and adults is equivocal. Whether adolescents are more or less sensitive to ethanol-induced impairment of spatial memory acquisition remains unclear; with regard to the effects of acute ethanol on spatial memory retrieval there is almost no research looking into any age difference. Thus, we examined the effects of acute ethanol on spatial memory in the Morris Watermaze in adolescents and adults. Allopregnanolone (ALLO) is a modulator of the GABA(A) receptor and has similar behavioral effects as ethanol. We sought to also determine the effects of allopreganolone on spatial memory in adolescent and adults. Male adolescent (post natal [PN]28-30) and adult (PN70-72) rats were trained in the Morris Watermaze for 6 days and acute doses of ethanol (saline, 1.5 and 2.0 g/kg) or ALLO (vehicle, 9 and 18 mg/kg) were administered on Day 7. A probe trial followed on Day 8. As expected, there were dose effects; higher doses of both ethanol and ALLO impaired spatial memory. However, in both the ethanol and ALLO conditions adolescents and adults had similar spatial memory impairments. The current results suggest that ethanol and ALLO both impair hippocampal-dependent spatial memory regardless of age in that once learning has occurred, ethanol or ALLO does not differentially impair the retrieval of spatial memory in adolescents and adults. Given the mixed results on the effect of ethanol on cognition in adolescent rats, additional research is needed to ascertain the factors critical for the reported differential results. (C) 2011 Elsevier Inc. All rights reserved.